{"id":"W3196649086","doi":"10.1101/2021.08.29.21261962","title":"SIOP Ependymoma I: Final results, long term follow-up and molecular analysis of the trial cohort: A BIOMECA Consortium Study","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"NIHR Great Ormond Street Hospital Biomedical Research Centre; Associazione Bianca Garavaglia; Brain Tumour Charity; Great Ormond Street Hospital Charity; CHILDREN with CANCER UK; University of Birmingham; Great Ormond Street Institute of Child Health; James Tudor Foundation; National Institute for Health and Care Research; Cancer Research UK","keywords":"Medicine; Ependymoma; Internal medicine; Oncology; Hazard ratio; Etoposide; Vincristine; Radiation therapy; Chemotherapy; Confidence interval; Surgery; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004309032,0.0007997596,0.001400503,0.0003520485,0.0005068717,0.001468471,0.0007419197,0.000698684,0.003106002],"category_scores_gemma":[0.005622665,0.0002960421,0.001589325,0.0008977807,0.0005059545,0.0005237814,0.0008345378,0.0008032282,0.0007331026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006221365,"about_ca_system_score_gemma":0.001300944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001686592,"about_ca_topic_score_gemma":0.002606898,"domain_scores_codex":[0.9978442,0.001156564,0.0001311414,0.0003891989,0.0002651132,0.0002137451],"domain_scores_gemma":[0.9958254,0.0008745984,0.001303312,0.0009604155,0.000434626,0.0006016177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3569582,0.001812088,0.5645373,0.00196542,0.01454351,0.001583886,0.0005228775,0.0009413931,0.005571833,0.0008542874,0.01290659,0.03780255],"study_design_scores_gemma":[0.09104308,0.03607739,0.8342997,0.0006121004,0.01532367,0.001933643,0.0003828387,0.0011635,0.002318732,0.0008229315,0.01591164,0.0001107636],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843807,0.003227533,0.0007511479,0.0003582584,0.00007371447,0.0008989921,0.008082269,0.00003370584,0.002193663],"genre_scores_gemma":[0.9776148,0.001045684,0.001126067,0.0003433474,0.0001788502,0.001925757,0.01497445,0.00006168467,0.002729413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004309032,"threshold_uncertainty_score":0.02278858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03608814515351018,"score_gpt":0.3092203051715464,"score_spread":0.2731321600180362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}