{"id":"W3196651177","doi":"10.1016/j.ijpharm.2021.121063","title":"Cocrystals, Salts, and Salt-Solvates of olanzapine; selection of coformers and improved solubility","year":2021,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Crystallography and molecular interactions","field":"Chemistry","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Cocrystal; Chemistry; Terephthalic acid; Solubility; Hydrogen bond; Crystal engineering; Organic chemistry; Inorganic chemistry; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003710586,0.0004251937,0.0005167171,0.0003377573,0.0002410502,0.0004635405,0.0003782291,0.0003048791,0.001759472],"category_scores_gemma":[0.0009040569,0.0001829515,0.0002201481,0.0003575093,0.0002352598,0.0002589399,0.0005044646,0.0003333801,0.0005561421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003541999,"about_ca_system_score_gemma":0.0004892232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001621456,"about_ca_topic_score_gemma":0.00449547,"domain_scores_codex":[0.9996183,0.00007304434,0.00005481008,0.00007887941,0.0001161596,0.00005876519],"domain_scores_gemma":[0.9996527,0.00008469632,0.00007674856,0.00002413021,0.000079795,0.00008185542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001016179,0.0001131456,0.0005717452,0.0001748179,0.00003909825,0.0002128844,0.00005925014,0.0005112669,0.9897054,0.0001583189,0.0007002476,0.006737833],"study_design_scores_gemma":[0.00007321588,0.0004831198,0.0007141716,0.0000113142,0.00003839516,0.0001111626,0.00002617665,0.001020034,0.994991,0.00001616067,0.002500426,0.0000149132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899212,0.001666407,0.003106535,0.0002140267,0.0001149792,0.0001554284,0.0007375604,0.0002760401,0.003807929],"genre_scores_gemma":[0.9895153,0.001102666,0.005813524,0.00008654391,0.00003009516,0.00006610603,0.00047705,0.000121348,0.00278741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001759472,"threshold_uncertainty_score":0.005886018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01611449669158925,"score_gpt":0.3204232449216449,"score_spread":0.3043087482300557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}