{"id":"W3196655613","doi":"10.1172/jci138230","title":"T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; University of California, San Diego; Monash University; Crohn's and Colitis Foundation; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Pfizer; Janssen Pharmaceuticals; Crohn's and Colitis Foundation of America","keywords":"Tight junction; Occludin; Claudin; Protein tyrosine phosphatase; Intestinal permeability; Cell biology; Barrier function; Biology; Inflammatory bowel disease; Paracellular transport; Cancer research; Immunology; Signal transduction; Internal medicine; Medicine; Biochemistry; Permeability (electromagnetism)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.001531086,0.0002168144,0.0004504894,0.0001137881,0.0003663372,0.0001262165,0.000150463,0.0002082138,0.00007052751],"category_scores_gemma":[0.01445021,0.0001794444,0.0002313135,0.0006199662,0.000210423,0.0007321506,0.00006881088,0.001089185,0.00002042351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006111143,"about_ca_system_score_gemma":0.0004361936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009530708,"about_ca_topic_score_gemma":0.000002179398,"domain_scores_codex":[0.9961814,0.0006599983,0.001784081,0.0004402241,0.0006834979,0.0002508457],"domain_scores_gemma":[0.9965494,0.0005653663,0.001605351,0.0002270877,0.0007372112,0.0003155845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005696036,0.0001048195,0.001416955,0.00004978689,0.00001869862,0.00004385287,0.0001165729,0.0002203826,0.9750329,0.0003683373,0.00868826,0.01336986],"study_design_scores_gemma":[0.001639477,0.000741941,0.001573792,0.0002070126,0.00009991891,0.0001354325,0.000162677,0.00158431,0.9743964,0.006563346,0.01267194,0.0002237311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658852,0.0007747796,0.02721021,0.001736082,0.003411352,0.0003242142,0.00001510564,0.00006193791,0.0005811054],"genre_scores_gemma":[0.9907569,0.0001083528,0.004820717,0.001750799,0.001681116,0.000009441217,0.00001090469,0.00002787106,0.0008338455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02487173,"threshold_uncertainty_score":0.9938515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07149544681708048,"score_gpt":0.319902093367877,"score_spread":0.2484066465507965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}