{"id":"W3196655613","doi":"10.1172/jci138230","title":"T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; University of California, San Diego; Monash University; Crohn's and Colitis Foundation; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Pfizer; Janssen Pharmaceuticals; Crohn's and Colitis Foundation of America","keywords":"Tight junction; Occludin; Claudin; Protein tyrosine phosphatase; Intestinal permeability; Cell biology; Barrier function; Biology; Inflammatory bowel disease; Paracellular transport; Cancer research; Immunology; Signal transduction; Internal medicine; Medicine; Biochemistry; Permeability (electromagnetism)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000158281,0.000242605,0.0001969421,0.0001967548,0.0001123528,0.0002677683,0.0001174452,0.0002494743,0.0006336594],"category_scores_gemma":[0.0001932196,0.00007932875,0.0001641326,0.0001276302,0.0001863208,0.0001394921,0.0001668261,0.0002768898,0.00008510659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001655727,"about_ca_system_score_gemma":0.0001587329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004217541,"about_ca_topic_score_gemma":0.0005043895,"domain_scores_codex":[0.9998952,0.00003093161,0.000008774344,0.00002881978,0.00001704777,0.00001910893],"domain_scores_gemma":[0.999922,0.000006532832,0.00003543089,0.000006856195,0.00000941805,0.00001971052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005190445,0.00004519627,0.005004676,0.00007545498,0.00004657939,0.0002030267,0.00003288189,0.0000910259,0.9891395,0.00009996981,0.00006245602,0.004680172],"study_design_scores_gemma":[0.0001424245,0.001923852,0.1558315,0.00003233458,0.0001988789,0.003247864,0.0001903603,0.002523653,0.8310804,0.0004646139,0.004352071,0.0000120295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960472,0.002400065,0.001051316,0.00007139693,0.00001038684,0.000005836416,0.00006190922,0.00001992383,0.0003321173],"genre_scores_gemma":[0.998709,0.0006824913,0.0003102801,0.00001502316,0.000004304601,0.000004405035,0.00004859062,0.00000240854,0.0002236216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006336594,"threshold_uncertainty_score":0.00211978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07149544681708048,"score_gpt":0.319902093367877,"score_spread":0.2484066465507965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}