{"id":"W3196656744","doi":"10.1002/jimd.12434","title":"Human and animal fertility studies in cystinosis reveal signs of obstructive azoospermia, an altered blood‐testis barrier and a subtherapeutic effect of cysteamine in testis","year":2021,"lang":"en","type":"article","venue":"Journal of Inherited Metabolic Disease","topic":"Biomedical Research and Pathophysiology","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"University of California, San Diego; Cystinosis Ireland; Fonds Wetenschappelijk Onderzoek; Universitaire Ziekenhuizen Leuven, KU Leuven; Health Research Charities Ireland; Medical Research Charities Group; Vlaamse regering; Cystinosis Research Foundation","keywords":"Cystinosis; Cysteamine; Azoospermia; Endocrinology; Lysosomal storage disease; Internal medicine; Obstructive azoospermia; Spermatogenesis; Biology; Cystine; Medicine; Andrology; Infertility; Genetics; Disease; Biochemistry; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007863825,0.0001931114,0.001190401,0.0003282683,0.00002875556,0.000007172147,0.00008471376,0.00009514691,0.0000321012],"category_scores_gemma":[0.003556259,0.0001427612,0.0001096208,0.0005642181,0.0006720243,0.0001231886,0.0000788764,0.000394269,1.07756e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002684794,"about_ca_system_score_gemma":0.0002648881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008441804,"about_ca_topic_score_gemma":0.00003268095,"domain_scores_codex":[0.9975212,0.0007725109,0.0008006864,0.0002588683,0.0003753372,0.000271459],"domain_scores_gemma":[0.9980118,0.0004645725,0.0002905152,0.0002024911,0.0004245746,0.000606093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003293285,0.0005338999,0.3513978,0.0009101495,0.0002361771,0.0009517585,0.0004568791,6.832856e-7,0.6360033,0.000007753084,0.000004394876,0.006203918],"study_design_scores_gemma":[0.006077759,0.003707561,0.9750959,0.0008388722,0.0004968804,0.0001539477,0.0002755489,0.00004289198,0.01292594,0.000273765,0.00001098389,0.0000999222],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662359,0.03324494,0.000001395082,0.0001400696,0.00003924706,0.0002566126,0.00007157733,0.00000345567,0.000006845012],"genre_scores_gemma":[0.9983271,0.001101975,0.0003587369,0.00007933631,0.00008746998,0.0000103602,0.000007754739,0.00001409703,0.00001315051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6236981,"threshold_uncertainty_score":0.5821634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04611743251032004,"score_gpt":0.3706397652590274,"score_spread":0.3245223327487073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}