{"id":"W3196656744","doi":"10.1002/jimd.12434","title":"Human and animal fertility studies in cystinosis reveal signs of obstructive azoospermia, an altered blood‐testis barrier and a subtherapeutic effect of cysteamine in testis","year":2021,"lang":"en","type":"article","venue":"Journal of Inherited Metabolic Disease","topic":"Biomedical Research and Pathophysiology","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"University of California, San Diego; Cystinosis Ireland; Fonds Wetenschappelijk Onderzoek; Universitaire Ziekenhuizen Leuven, KU Leuven; Health Research Charities Ireland; Medical Research Charities Group; Vlaamse regering; Cystinosis Research Foundation","keywords":"Cystinosis; Cysteamine; Azoospermia; Endocrinology; Lysosomal storage disease; Internal medicine; Obstructive azoospermia; Spermatogenesis; Biology; Cystine; Medicine; Andrology; Infertility; Genetics; Disease; Biochemistry; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003628361,0.0002395642,0.0002412369,0.0004446537,0.0002436321,0.0001326102,0.0001335706,0.0003100179,0.002327675],"category_scores_gemma":[0.0002103593,0.0001148593,0.0002344039,0.0001821565,0.0004924097,0.0001702085,0.0001509315,0.0002522226,0.0001858123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001852491,"about_ca_system_score_gemma":0.0001657785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009776922,"about_ca_topic_score_gemma":0.001032481,"domain_scores_codex":[0.9998627,0.00004530805,0.00001257832,0.00003280986,0.00002833541,0.00001818767],"domain_scores_gemma":[0.9998637,0.00003477181,0.00003352715,0.00001705754,0.00001890309,0.00003198076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00160691,0.0004126575,0.008233443,0.0003797217,0.00006382435,0.002330866,0.000301443,0.0001079412,0.9769305,0.0004945474,0.0003122422,0.008825935],"study_design_scores_gemma":[0.0001654471,0.02301297,0.1172277,0.0001021439,0.000233799,0.02099899,0.0005352097,0.0006164901,0.8195057,0.0003655161,0.01719741,0.0000384935],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868596,0.008039107,0.001367308,0.0001050304,0.00004661923,0.00009189037,0.000337753,0.0000519562,0.003100658],"genre_scores_gemma":[0.9945689,0.002150632,0.0006048901,0.00005423004,0.00001019341,0.00003248068,0.0002598659,0.000006154413,0.002312513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002327675,"threshold_uncertainty_score":0.00778687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04611743251032004,"score_gpt":0.3706397652590274,"score_spread":0.3245223327487073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}