{"id":"W3196688703","doi":"10.3390/pharmaceutics13091435","title":"Novel Pyropheophorbide Phosphatydic Acids Photosensitizer Combined EGFR siRNA Gene Therapy for Head and Neck Cancer Treatment","year":2021,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Ministry of Science and Technology, Taiwan","keywords":"Photosensitizer; Photodynamic therapy; Cancer research; Small interfering RNA; Materials science; Chemistry; Transfection; Molecular biology; Medicine; Biology; Biochemistry; Gene; Photochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001586061,0.0003354377,0.00057557,0.00006769658,0.0002022608,0.00003836826,0.0000760562,0.00008308893,0.0001662861],"category_scores_gemma":[0.00006924201,0.0002748877,0.0001668872,0.0002360862,0.0001715478,0.00005376577,0.00006844079,0.0001924347,0.000005937321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003817264,"about_ca_system_score_gemma":0.0003726005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001581275,"about_ca_topic_score_gemma":0.00005871174,"domain_scores_codex":[0.998291,0.00004416145,0.0002841655,0.0004716645,0.0003174563,0.0005915791],"domain_scores_gemma":[0.9987172,0.0002179136,0.00009099585,0.0003288403,0.0003210806,0.0003238947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003124262,0.0008635938,0.003219195,0.00009714963,0.001225771,0.0001282949,0.0007020021,0.00001072145,0.9618536,0.00002531264,0.0003623347,0.02838775],"study_design_scores_gemma":[0.02549116,0.000927895,0.008909603,0.00007136517,0.000237358,0.00009978346,0.000123255,0.002767778,0.9060487,0.00008108775,0.05497898,0.0002630381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9646624,0.02944452,0.0001248121,0.003490133,0.0003224629,0.00143409,0.0002748683,0.00008530398,0.0001614493],"genre_scores_gemma":[0.8997256,0.08951935,0.00258061,0.004188827,0.0003025856,0.0004595542,0.00009516827,0.00008882985,0.003039539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06493682,"threshold_uncertainty_score":0.9999703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09054642819428688,"score_gpt":0.4126247262132075,"score_spread":0.3220782980189206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}