{"id":"W3196702900","doi":"10.1002/anie.202110819","title":"High‐Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild‐Type and B.1.1.7 SARS‐CoV‐2 in Unprocessed Saliva","year":2021,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"SARS-CoV-2 detection and testing","field":"Medicine","cited_by":168,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; McMaster University","funders":"Institute of Infection and Immunity","keywords":"Saliva; Aptamer; Wild type; Dissociation constant; Chemistry; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Molecular biology; Coronavirus disease 2019 (COVID-19); Chromatography; Virology; Biology; Receptor; Biochemistry; Medicine; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003524589,0.0004995388,0.0002324728,0.000248647,0.00009605577,0.000292745,0.0003208505,0.0006638985,0.0007689155],"category_scores_gemma":[0.0002942067,0.000268792,0.0002154172,0.0001236561,0.0002015336,0.0002179869,0.0002258768,0.0004128237,0.0004295729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002064491,"about_ca_system_score_gemma":0.0001385313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002935497,"about_ca_topic_score_gemma":0.0005604065,"domain_scores_codex":[0.999655,0.00006966945,0.00002041649,0.00007655108,0.0001413387,0.00003703067],"domain_scores_gemma":[0.9999042,0.00002638226,0.00002194613,0.000007225618,0.00002437453,0.00001594284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003834739,0.00002051071,0.0004804218,0.00003874547,0.000005442069,0.00002882343,0.00002498424,0.00007404161,0.9926402,0.00006877744,0.00007907634,0.006500673],"study_design_scores_gemma":[0.000012173,0.0003480725,0.002347634,0.0000054237,0.00001469714,0.0005603701,0.00002661131,0.002477024,0.9922801,0.00005860574,0.001858423,0.00001095311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9292815,0.005612764,0.06049891,0.0003810631,0.0001422333,0.0001610605,0.0002935095,0.0003701723,0.003258779],"genre_scores_gemma":[0.9437474,0.0009481311,0.05228965,0.0002114993,0.00002585534,0.00006064951,0.0001845298,0.000009593036,0.002522668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007689155,"threshold_uncertainty_score":0.002572298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02270728008149508,"score_gpt":0.2758217093776004,"score_spread":0.2531144292961053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}