{"id":"W3196722379","doi":"10.3390/genes12091349","title":"Thousands of CpGs Show DNA Methylation Differences in ACPA-Positive Individuals","year":2021,"lang":"en","type":"article","venue":"Genes","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; National Research Council Canada; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Differentially methylated regions; CpG site; Biology; Methylation; Genetics; Computational biology; Epigenetics; Bisulfite sequencing; Genome-wide association study; Gene; Single-nucleotide polymorphism; Gene expression; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003328292,0.0002031285,0.0002882259,0.0006896602,0.0004073158,0.0002852546,0.0002542909,0.0003074785,0.004247908],"category_scores_gemma":[0.00108157,0.0001381794,0.0003326423,0.001017869,0.0002263657,0.0001057224,0.0002621781,0.0002745908,0.0002450826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002941501,"about_ca_system_score_gemma":0.0002795903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02488947,"about_ca_topic_score_gemma":0.05079276,"domain_scores_codex":[0.9996828,0.00004341825,0.00002114164,0.0001500306,0.00004730532,0.00005542823],"domain_scores_gemma":[0.9996754,0.00009735115,0.00008341137,0.00005835521,0.00004139926,0.0000441808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001300008,0.00004367529,0.8970311,0.0001499193,0.0007990439,0.0004309253,0.0005112676,0.000382598,0.07664371,0.000213787,0.0007814189,0.02171254],"study_design_scores_gemma":[0.00002509331,0.00006241489,0.9966827,0.000008107914,0.0001287313,0.0003182101,0.00008306004,0.0003237095,0.001340083,0.0001293802,0.0008920229,0.000006333447],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959543,0.00049708,0.0006986556,0.00004125975,0.000006494542,0.00001316096,0.002290048,0.00002918056,0.0004698178],"genre_scores_gemma":[0.9980364,0.00009970791,0.0005729193,0.00004104108,0.000004841066,0.00001337834,0.0008643975,0.000007208868,0.0003600049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02488947,"threshold_uncertainty_score":0.0494892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01512566593346128,"score_gpt":0.2383682673272855,"score_spread":0.2232426013938242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}