{"id":"W3196745917","doi":"10.1172/jci148013","title":"Alveolar macrophages from persons living with HIV show impaired epigenetic response to Mycobacterium tuberculosis","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; Centre Hospitalier Universitaire Sainte-Justine; McGill University; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Epigenetics; Tuberculosis; Immune system; Human immunodeficiency virus (HIV); Innate immune system; Mycobacterium tuberculosis; Chromatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001248033,0.0001483183,0.0001654689,0.0003385625,0.0002661305,0.0003021156,0.00009002352,0.0002223515,0.001453195],"category_scores_gemma":[0.0002522901,0.0001264329,0.000100199,0.0001742264,0.000151834,0.0001071176,0.0002542037,0.0002187963,0.0002896898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004612339,"about_ca_system_score_gemma":0.00006599347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000350105,"about_ca_topic_score_gemma":0.0005258692,"domain_scores_codex":[0.9998966,0.00001904538,0.00001313246,0.00002359075,0.00002128062,0.0000262465],"domain_scores_gemma":[0.999885,0.00002612139,0.00002629635,0.00001345409,0.0000254147,0.00002375297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001136822,0.0001696513,0.1382846,0.00009566561,0.00004155186,0.0007769871,0.0006345725,0.00004813127,0.8501337,0.00005529002,0.0001503919,0.008472695],"study_design_scores_gemma":[0.00002293072,0.0008021144,0.9352733,0.00001870033,0.0000474612,0.002265472,0.00100415,0.0001711571,0.05914696,0.0001182334,0.001120338,0.000009229212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990628,0.0003240453,0.0001351103,0.00002114228,0.000005010442,0.00001195078,0.0001558779,0.000003794906,0.000280256],"genre_scores_gemma":[0.9985876,0.0002795634,0.0002275836,0.0000648252,0.0000150851,0.00002715549,0.0003384748,0.000001964076,0.0004577544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001453195,"threshold_uncertainty_score":0.004861414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06440302404834046,"score_gpt":0.3782829660190338,"score_spread":0.3138799419706934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}