{"id":"W3196755709","doi":"10.3389/fgene.2021.755076","title":"Editorial: Epigenetic Mechanisms and Their Involvement in Rare Diseases","year":2021,"lang":"en","type":"editorial","venue":"Frontiers in Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Children's Hospital Research Institute of Manitoba; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Ontario Rett Syndrome Association","keywords":"Epigenetics; Biology; Medicine; Computational biology; Genetics; Bioinformatics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003682163,0.0005303407,0.0006196974,0.0002412733,0.0000604384,0.00009459579,0.0003776296,0.001458916,0.000006417932],"category_scores_gemma":[0.0004102354,0.0005551282,0.0001314652,0.0002174887,0.0001059939,0.000003661441,0.0004029757,0.0004789781,9.011104e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001113053,"about_ca_system_score_gemma":0.0005342311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004138036,"about_ca_topic_score_gemma":0.0003808415,"domain_scores_codex":[0.9971214,0.0002570199,0.0006165631,0.001012951,0.0004817764,0.0005102831],"domain_scores_gemma":[0.9986382,0.0000648433,0.0002078468,0.0006949836,0.0002203957,0.0001737681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006392665,0.0001281667,0.003423729,0.0001591776,0.00007497569,0.000009715697,0.0001346675,0.000574214,0.0103863,0.000003090078,0.9802081,0.004833917],"study_design_scores_gemma":[0.001179795,0.0003189622,0.000396458,0.0001495092,0.00005028791,1.886899e-7,0.0003505939,0.0002094518,0.02192289,0.002863571,0.971855,0.0007032731],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.005382336,0.09655552,0.007994791,0.00002354542,0.8891562,0.0004564599,0.000373686,0.000009734638,0.0000477278],"genre_scores_gemma":[0.003341218,0.06375719,0.006618481,0.00003306417,0.9221841,0.0001270084,0.003533421,0.0001318622,0.0002737097],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.03302785,"threshold_uncertainty_score":0.9998374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005278715123275614,"score_gpt":0.2278829270148533,"score_spread":0.2226042118915777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}