{"id":"W3196758049","doi":"10.1136/bcr-2021-245018","title":"Carbamazepine drug effect simulating biochemical central hypothyroidism in a patient with Bardet-Biedl syndrome","year":2021,"lang":"en","type":"article","venue":"BMJ Case Reports","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Levothyroxine; Carbamazepine; Euthyroid; Central hypothyroidism; Medicine; Internal medicine; Epilepsy; Endocrinology; Ciliopathy; Reference range; Pediatrics; Thyroid; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003402478,0.001564399,0.001194078,0.002727885,0.001986919,0.001097067,0.001136981,0.004408587,0.002268286],"category_scores_gemma":[0.002703308,0.0009596696,0.001054214,0.001452514,0.001577361,0.00130374,0.001298637,0.003049555,0.0005088125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001695439,"about_ca_system_score_gemma":0.0009708147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006905074,"about_ca_topic_score_gemma":0.007961091,"domain_scores_codex":[0.9994196,0.0000677439,0.00007472537,0.0001151495,0.0001126483,0.0002101728],"domain_scores_gemma":[0.9982288,0.0005780206,0.0002604578,0.00007242915,0.0001002816,0.0007599227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00005008274,0.00002197436,0.003788867,0.00001704784,0.000005807314,0.9948144,0.0001010128,0.00003974616,0.0005887694,0.00006874873,0.0001105939,0.0003930471],"study_design_scores_gemma":[0.0000213423,0.0001007059,0.008000642,0.00001298598,0.00001529258,0.9908075,0.00008345996,0.0002531189,0.0003583424,0.0001068661,0.0002265088,0.00001330293],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830865,0.002669798,0.001404943,0.00456264,0.0002524968,0.0001448055,0.0001923017,0.0001989282,0.007487551],"genre_scores_gemma":[0.9974391,0.0004545756,0.0004390456,0.0007297072,0.0002219759,0.000008532202,0.00004616527,0.0000180843,0.0006426866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006905074,"threshold_uncertainty_score":0.01372975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004414518612669494,"score_gpt":0.2331648090065307,"score_spread":0.2287502903938612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}