{"id":"W3196770390","doi":"10.1093/hmg/ddab274","title":"Methylome-wide association study of early life stressors and adult mental health","year":2021,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Economic and Social Research Council; Biotechnology and Biological Sciences Research Council; Medical Research Council; NIHR Maudsley Biomedical Research Centre; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Directorate for Biological Sciences; Medical Research Council Canada; University of Queensland; Brain and Behavior Research Foundation; Department of Health and Social Care; University of Edinburgh; National Institute for Health and Care Research; King's College London; National Alliance for Research on Schizophrenia and Depression; UK Research and Innovation; Age UK; National Health and Medical Research Council; Scottish Funding Council; Scottish Government; Centre for Cognitive Ageing and Cognitive Epidemiology; South London and Maudsley NHS Foundation Trust; Wellcome Trust","keywords":"Biology; DNA methylation; Epigenetics; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002556554,0.000167717,0.000238536,0.00005292146,0.000126903,0.00003748076,0.0001076372,0.0001315315,0.00001013192],"category_scores_gemma":[0.0002338717,0.0001945739,0.00007009422,0.0001159114,0.00003033695,0.00000241054,0.000156973,0.00009211816,0.000001264195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002862346,"about_ca_system_score_gemma":0.0001091911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000688828,"about_ca_topic_score_gemma":0.0002328327,"domain_scores_codex":[0.9983252,0.0002932976,0.0004192101,0.0003956519,0.0003285746,0.0002380614],"domain_scores_gemma":[0.9988884,0.00001864954,0.0002763289,0.000375533,0.0002929528,0.0001481147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001715356,0.0003539344,0.1923955,0.00002874638,0.0001981749,0.00000447786,0.0007875335,0.000176096,0.8049168,0.00006956622,0.0002207937,0.0008311836],"study_design_scores_gemma":[0.001848502,0.002013613,0.4261326,0.00001723609,0.00006776432,6.887533e-7,0.0009792495,0.0000294093,0.5666057,0.0003055581,0.001678771,0.0003208896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992109,0.006557191,0.0005527234,0.000211113,0.00006632427,0.0002895053,0.00002510067,0.000007222452,0.0001817969],"genre_scores_gemma":[0.9974425,0.001002584,0.0007800012,0.0003253638,0.00005263568,0.00001043149,0.0001810871,0.00003308287,0.0001722843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2383111,"threshold_uncertainty_score":0.7934492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256067004689505,"score_gpt":0.2879216497596067,"score_spread":0.2753609797127116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}