{"id":"W3196770390","doi":"10.1093/hmg/ddab274","title":"Methylome-wide association study of early life stressors and adult mental health","year":2021,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Economic and Social Research Council; Biotechnology and Biological Sciences Research Council; Medical Research Council; NIHR Maudsley Biomedical Research Centre; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Directorate for Biological Sciences; Medical Research Council Canada; University of Queensland; Brain and Behavior Research Foundation; Department of Health and Social Care; University of Edinburgh; National Institute for Health and Care Research; King's College London; National Alliance for Research on Schizophrenia and Depression; UK Research and Innovation; Age UK; National Health and Medical Research Council; Scottish Funding Council; Scottish Government; Centre for Cognitive Ageing and Cognitive Epidemiology; South London and Maudsley NHS Foundation Trust; Wellcome Trust","keywords":"Biology; DNA methylation; Epigenetics; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005836299,0.0002078554,0.0003466473,0.0005878477,0.0003698422,0.0003451058,0.0003047135,0.0004001618,0.002079282],"category_scores_gemma":[0.001658024,0.0001404247,0.0005481614,0.001335682,0.0001388453,0.0001678304,0.0004712579,0.0005369316,0.0001567271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002732206,"about_ca_system_score_gemma":0.000230407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01292366,"about_ca_topic_score_gemma":0.01424325,"domain_scores_codex":[0.9995046,0.0001627546,0.00003178205,0.0001702927,0.00006621522,0.0000642744],"domain_scores_gemma":[0.9992092,0.0001559386,0.000288599,0.0001000941,0.00009538293,0.000150761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005752193,0.00003024007,0.9904906,0.00004785279,0.001013792,0.000116911,0.00009745503,0.00007866631,0.003496303,0.00007445718,0.0004405934,0.003538111],"study_design_scores_gemma":[0.000006723771,0.00002956448,0.9994863,0.000003756051,0.00006532587,0.00004785056,0.00002096652,0.00006638232,0.00006332529,0.00002532411,0.00018263,0.000001840718],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938876,0.001160275,0.0004160253,0.0001902895,0.00001747433,0.00001237025,0.003688727,0.00001259777,0.0006147002],"genre_scores_gemma":[0.9978507,0.0002829742,0.000212933,0.00005648964,0.00001206793,0.00001615795,0.001214732,0.000003453704,0.0003505099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01292366,"threshold_uncertainty_score":0.02569687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256067004689505,"score_gpt":0.2879216497596067,"score_spread":0.2753609797127116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}