{"id":"W3196779238","doi":"10.1021/acs.joc.1c01380","title":"Copper-Catalyzed Conjugate Addition of Carbonyls as Carbanion Equivalent via Hydrazones","year":2021,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Catalytic Cross-Coupling Reactions","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre in Green Chemistry and Catalysis","funders":"Canada Foundation for Innovation; Centre in Green Chemistry and Catalysis; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; McGill University","keywords":"Chemistry; Hydrazone; Carbanion; Conjugate; Umpolung; Reactivity (psychology); Copper; Phosphine; Catalysis; Denticity; Addition reaction; Adduct; Medicinal chemistry; Conjugated system; Organic chemistry; Polymer chemistry; Combinatorial chemistry; Metal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002883427,0.000705576,0.0003419896,0.0003096936,0.000247091,0.0002448425,0.0005714001,0.0004115845,0.002018278],"category_scores_gemma":[0.0003255131,0.0002645915,0.0002653585,0.0003514187,0.0003469993,0.0004918433,0.0006064195,0.0006152839,0.000612936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003965595,"about_ca_system_score_gemma":0.0003092015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003938477,"about_ca_topic_score_gemma":0.0007259463,"domain_scores_codex":[0.9997436,0.00005122666,0.00001933157,0.00006081159,0.00004242815,0.00008258765],"domain_scores_gemma":[0.9998534,0.00002256454,0.00003640168,0.00002870469,0.0000263173,0.00003258721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002306638,0.0001005957,0.0002946889,0.0003499778,0.0000476212,0.0005365628,0.0002012767,0.0009474152,0.9822906,0.003780644,0.0006234306,0.01059659],"study_design_scores_gemma":[0.00001095409,0.0002599206,0.0001974952,0.000004946647,0.00001549472,0.0001720302,0.000009442079,0.0004139775,0.9961292,0.00007127137,0.002706988,0.000008418351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9530976,0.002908336,0.02910849,0.000271362,0.0001429822,0.0001943062,0.0003248215,0.0005312727,0.01342079],"genre_scores_gemma":[0.9897775,0.001172047,0.006026463,0.00004454278,0.00002168706,0.00005471212,0.0001320977,0.00003588939,0.002735015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002018278,"threshold_uncertainty_score":0.006751776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009429735492262444,"score_gpt":0.2435700935631586,"score_spread":0.2341403580708962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}