{"id":"W3196800277","doi":"10.20944/preprints202109.0032.v1","title":"Pseudomonas Aeruginosa Antibiotic Efflux Pump Variants Exhibit Increased Virulence","year":2021,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Clinical and Translational Science Institute, University of California, Los Angeles; National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Efflux; Virulence; Pseudomonas aeruginosa; Rhamnolipid; Microbiology; Biology; Virulence factor; Swarming motility; Antibiotic resistance; Antibiotics; Pyocyanin; Gene; Bacteria; Genetics; Quorum sensing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001619364,0.000482062,0.0004446053,0.0003325149,0.0001548344,0.0004777956,0.0001632496,0.0007438145,0.002342345],"category_scores_gemma":[0.0003522658,0.000176764,0.0003314477,0.0002769209,0.0002427405,0.0001820367,0.0003389429,0.0009989509,0.0008760706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002025068,"about_ca_system_score_gemma":0.0001190738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003850873,"about_ca_topic_score_gemma":0.0003091976,"domain_scores_codex":[0.9996246,0.00007407517,0.00004039525,0.00006384966,0.0001290464,0.00006804064],"domain_scores_gemma":[0.9997036,0.00006501163,0.0000922824,0.00004718465,0.00003459083,0.00005744006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000509124,0.00002072821,0.0002354561,0.00001523377,0.000004084055,0.00008629623,0.000009520052,0.00002392943,0.9987674,0.00003602024,0.00006284169,0.0006876505],"study_design_scores_gemma":[0.00003102995,0.0006234304,0.03459558,0.00001210712,0.00003421876,0.002637753,0.00008850263,0.0009574991,0.95642,0.0001751925,0.004400312,0.00002437574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932281,0.0009291758,0.002407262,0.0003918338,0.00006324314,0.00002509215,0.000796816,0.0001983827,0.001960124],"genre_scores_gemma":[0.9944592,0.0003659574,0.001487384,0.0001595538,0.00001742439,0.00002660644,0.0007128749,0.0001084132,0.002662601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002342345,"threshold_uncertainty_score":0.007835925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04313759046909515,"score_gpt":0.3058664412258245,"score_spread":0.2627288507567293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}