{"id":"W3196802127","doi":"10.3390/toxins13090607","title":"Anti-Virulence Strategy against the Honey Bee Pathogenic Bacterium Paenibacillus larvae via Small Molecule Inhibitors of the Bacterial Toxin Plx2A","year":2021,"lang":"en","type":"article","venue":"Toxins","topic":"Insect and Pesticide Research","field":"Agricultural and Biological Sciences","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Ministère de la Défense Nationale; Deutsche Forschungsgemeinschaft","keywords":"American foulbrood; Virulence; Biology; Microbiology; Bioassay; Brood; In vitro toxicology; Toxin; Virulence factor; In vitro; Botany; Spore; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000831328,0.0002972205,0.0001784997,0.0001959575,0.00008577166,0.0001672756,0.0001245765,0.0001724414,0.0009096738],"category_scores_gemma":[0.00007195414,0.00005861362,0.0001558655,0.000100687,0.0001049542,0.000115375,0.0001030641,0.0002815092,0.0001399812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001438607,"about_ca_system_score_gemma":0.00013393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003553056,"about_ca_topic_score_gemma":0.0013148,"domain_scores_codex":[0.9999684,0.000007189486,0.000002652846,0.000006117765,0.000008234457,0.000007383502],"domain_scores_gemma":[0.9999713,0.000007349269,0.000007649657,0.000002164918,0.00000476893,0.000006819629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008312373,0.00006933486,0.0001714306,0.00008095615,0.000008134988,0.00005839995,0.000009311816,0.0001280582,0.995869,0.00005965736,0.00004785381,0.003414681],"study_design_scores_gemma":[0.0001286124,0.002915312,0.00694049,0.00001908823,0.00003660307,0.0003085901,0.00003801234,0.0009746864,0.9842067,0.00005226857,0.004372892,0.000006837058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919205,0.003749254,0.001783859,0.0001293982,0.00002240521,0.0001079179,0.0003262509,0.00005095655,0.001909531],"genre_scores_gemma":[0.9894545,0.003629889,0.004004813,0.0001027231,0.00001273699,0.00007162379,0.0004288963,0.000007908304,0.002286922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009096738,"threshold_uncertainty_score":0.003043175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02398416280765557,"score_gpt":0.2235840852855896,"score_spread":0.199599922477934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}