{"id":"W3196810602","doi":"10.1093/jnen/nlab090","title":"Nuclear IMPDH Filaments in Human Gliomas","year":2021,"lang":"en","type":"article","venue":"Journal of Neuropathology & Experimental Neurology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital; St. Michael's Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; Ottawa Hospital Research Institute; Howard Hughes Medical Institute","keywords":"Cancer research; Glioma; Chemistry; Computational biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002700093,0.0001770725,0.0002979292,0.0001325262,0.00005914935,0.00001608496,0.0003338718,0.0002357301,0.00007426106],"category_scores_gemma":[0.0001325186,0.0001744342,0.0001811473,0.0001468583,0.000217308,0.000006976919,0.0004095962,0.0004878776,0.000008339256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001330842,"about_ca_system_score_gemma":0.00006099159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002191774,"about_ca_topic_score_gemma":0.000003393532,"domain_scores_codex":[0.9980863,0.0004228532,0.0005105289,0.0003867686,0.0001853609,0.0004081864],"domain_scores_gemma":[0.9992403,0.00001872519,0.0001879702,0.0002933241,0.0001074745,0.0001522304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004560892,0.0004921822,0.00373035,0.000004551839,0.00001776482,0.006977905,0.00003977309,0.000004666009,0.9874026,0.00006864937,0.0006579855,0.0001474684],"study_design_scores_gemma":[0.001411511,0.002543087,0.008567325,0.000005073883,0.000006505628,0.008601281,0.00005052512,0.000002342375,0.9696462,0.00004623291,0.008992731,0.0001272163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971194,0.001321962,0.00001875455,0.0005424092,0.0003506616,0.00006979388,0.000002107031,0.000004701057,0.0005701574],"genre_scores_gemma":[0.996914,0.0000898202,0.0001395912,0.002513708,0.0002063042,0.000002421521,0.00001173489,0.00003706348,0.00008536541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01775645,"threshold_uncertainty_score":0.7113222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01199039547581251,"score_gpt":0.2993253982954498,"score_spread":0.2873350028196373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}