{"id":"W3196867527","doi":"10.3389/fnins.2021.718244","title":"Cerebroventricular Microinjections of MPTP on Adult Zebrafish Induces Dopaminergic Neuronal Death, Mitochondrial Fragmentation, and Sensorimotor Impairments","year":2021,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Dopaminergic; MPTP; PINK1; Zebrafish; Parkin; Neuroscience; Mitophagy; Biology; Mitochondrion; Neurotoxin; Monoaminergic; Cell biology; Dopamine transporter; Dopamine; Parkinson's disease; Endocrinology; Internal medicine; Autophagy; Medicine; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000771486,0.0001184855,0.0001281897,0.0001252721,0.0000904325,0.00003518637,0.0002185676,0.00007917888,0.000005656054],"category_scores_gemma":[0.0007034561,0.000119611,0.00004948984,0.0004918287,0.0002587886,0.00001208786,0.0001343406,0.0001387098,0.000001268394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002489086,"about_ca_system_score_gemma":0.0001652383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001734606,"about_ca_topic_score_gemma":0.000007169527,"domain_scores_codex":[0.9985101,0.00009876134,0.0002302078,0.0005524572,0.0003393835,0.0002691249],"domain_scores_gemma":[0.9993618,0.00002248479,0.00007646489,0.0002697468,0.0001202783,0.0001492932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003525013,0.0002244951,0.01339495,0.00001253158,0.000005036524,0.00001711815,0.00001511957,0.00003473386,0.980637,0.00008311695,0.00514504,0.0003955874],"study_design_scores_gemma":[0.001606625,0.0007411464,0.1739409,0.00003311296,0.00001334391,0.00007790001,0.0001404569,0.0005766515,0.8129574,0.0003988685,0.009258008,0.0002555486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956611,0.0000895692,0.002659383,0.0004645184,0.000630543,0.0002377169,0.00005848863,0.000006768778,0.0001919446],"genre_scores_gemma":[0.995358,0.0002592891,0.003194338,0.0007269207,0.000108835,0.00003844616,0.00004621059,0.00001275785,0.0002551655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1676796,"threshold_uncertainty_score":0.4877594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008825586283820207,"score_gpt":0.2635820185150825,"score_spread":0.2547564322312623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}