{"id":"W3196867527","doi":"10.3389/fnins.2021.718244","title":"Cerebroventricular Microinjections of MPTP on Adult Zebrafish Induces Dopaminergic Neuronal Death, Mitochondrial Fragmentation, and Sensorimotor Impairments","year":2021,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Dopaminergic; MPTP; PINK1; Zebrafish; Parkin; Neuroscience; Mitophagy; Biology; Mitochondrion; Neurotoxin; Monoaminergic; Cell biology; Dopamine transporter; Dopamine; Parkinson's disease; Endocrinology; Internal medicine; Autophagy; Medicine; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001245007,0.0006255875,0.0003136251,0.0005713843,0.0002960435,0.0002250187,0.0002987868,0.0004615542,0.001759474],"category_scores_gemma":[0.00009705014,0.0001914651,0.0004002309,0.0001561569,0.0005223264,0.0003093085,0.0002756247,0.001039341,0.0002887862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007365924,"about_ca_system_score_gemma":0.0006237898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004827623,"about_ca_topic_score_gemma":0.01151214,"domain_scores_codex":[0.9998283,0.000006793049,0.00001484067,0.00005401008,0.00004875292,0.00004722043],"domain_scores_gemma":[0.9998618,0.00001253214,0.00005157907,0.00001161793,0.0000206606,0.00004171801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005380421,0.00002050529,0.0001438455,0.00004225587,0.000005269106,0.00009787881,0.00003300111,0.00004014399,0.9987997,0.0001037825,0.00004414871,0.0006157461],"study_design_scores_gemma":[0.00002173975,0.0005153471,0.006573269,0.00002052034,0.00003518018,0.0002081136,0.00006397339,0.0006296353,0.9905239,0.00009964471,0.001298972,0.000009706109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884529,0.001391905,0.004005067,0.0002958837,0.0001006859,0.0001006181,0.001865659,0.0003188325,0.003468571],"genre_scores_gemma":[0.9778402,0.001890342,0.007504274,0.0001914772,0.00002294237,0.0002222452,0.001153719,0.00009306034,0.01108172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004827623,"threshold_uncertainty_score":0.00959903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008825586283820207,"score_gpt":0.2635820185150825,"score_spread":0.2547564322312623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}