{"id":"W3196893334","doi":"10.1097/qad.0000000000003002","title":"Ritonavir-boosted antiretroviral therapy precipitating tacrolimus toxicity in a renal transplant patient: is it time for a priori tacrolimus dosage reduction?","year":2021,"lang":"en","type":"letter","venue":"AIDS","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Tacrolimus; Ritonavir; Medicine; Toxicity; Renal transplant; Pharmacology; Transplantation; Antiretroviral therapy; Internal medicine; Human immunodeficiency virus (HIV); Immunology; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001835748,0.0006629297,0.001181459,0.0006832682,0.0001552465,0.00008509008,0.0001748924,0.0007921291,0.0003670826],"category_scores_gemma":[0.00002496993,0.0005644254,0.0006485137,0.0007618056,0.00008082043,0.0001714178,0.00001782382,0.001152696,0.00004297719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001916247,"about_ca_system_score_gemma":0.0002285271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002027668,"about_ca_topic_score_gemma":0.000008690707,"domain_scores_codex":[0.9964522,0.000195939,0.0009708951,0.0009347322,0.0006936561,0.0007526233],"domain_scores_gemma":[0.9985821,0.0002872813,0.0003269977,0.0005025128,0.0001723394,0.0001287457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01869965,0.005638971,0.05058194,0.01032932,0.01395562,0.04278864,0.08092889,0.00008221759,0.1445027,0.00006295315,0.4561403,0.1762888],"study_design_scores_gemma":[0.08569541,0.03340102,0.01884927,0.02498821,0.00476446,0.007050582,0.0008733796,0.0007036682,0.1376111,0.0003554139,0.6803858,0.005321705],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8751137,0.001690231,0.0001779115,0.1114625,0.001076323,0.004557513,0.003878523,0.0001744813,0.00186879],"genre_scores_gemma":[0.5100639,0.005034846,0.01536426,0.4110352,0.005363993,0.001595502,0.02428869,0.0006279982,0.02662563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3650498,"threshold_uncertainty_score":0.9996807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02867799754260787,"score_gpt":0.3001266618978902,"score_spread":0.2714486643552824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}