{"id":"W3196905322","doi":"10.3390/vaccines9090975","title":"Incorporating the Cluster A and V1V2 Targets into a Minimal Structural Unit of the HIV-1 Envelope to Elicit a Cross-Clade Response with Potent Fc-Effector Functions","year":2021,"lang":"en","type":"article","venue":"Vaccines","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Epitope; Effector; Immunogen; Antibody; Virology; Biology; Antigen; Polyclonal antibodies; Immunology; Computational biology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002048715,0.0004290886,0.0002353929,0.0002618054,0.0001930738,0.0003293809,0.0004445276,0.0003853229,0.0009468181],"category_scores_gemma":[0.0001404749,0.0001692966,0.0003130763,0.0001505579,0.0002604403,0.0002945783,0.0004305638,0.0007394049,0.0003266786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006593145,"about_ca_system_score_gemma":0.0003717088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000742105,"about_ca_topic_score_gemma":0.0009752765,"domain_scores_codex":[0.999768,0.00003542056,0.00001692257,0.00005210594,0.00006319109,0.00006438042],"domain_scores_gemma":[0.999896,0.00001268292,0.00003033354,0.00001647929,0.00001176851,0.00003271591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008313316,0.00006866008,0.0002555746,0.00002946122,0.000008335811,0.00003793607,0.00001778288,0.0004205657,0.9977294,0.0002594142,0.0000368345,0.00105294],"study_design_scores_gemma":[0.00002719389,0.000872087,0.001430377,0.000005362756,0.00001953801,0.0002764942,0.0000181509,0.001539159,0.9919395,0.00006005261,0.003803504,0.000008615738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903155,0.0002884882,0.007768561,0.00007764495,0.00003547265,0.00009103205,0.0001726974,0.00006117434,0.001189424],"genre_scores_gemma":[0.9844298,0.0002514951,0.01268832,0.00006873436,0.00001160623,0.00003939786,0.0004816615,0.00003503216,0.001993951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009468181,"threshold_uncertainty_score":0.00478369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01132283280067205,"score_gpt":0.2673605312153634,"score_spread":0.2560376984146914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}