{"id":"W3197016818","doi":"10.1093/ecco-jcc/jjab153","title":"Adalimumab and Infliximab Impair SARS-CoV-2 Antibody Responses: Results from a Therapeutic Drug Monitoring Study in 11 422 Biologic-Treated Patients","year":2021,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Medical Research Council; Crohn's and Colitis UK; Public Health England; National Institute for Health and Care Research; Public Health Wales; Royal Devon and Exeter NHS Foundation Trust","keywords":"Medicine; Adalimumab; Infliximab; Therapeutic drug monitoring; Drug; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Drug holiday; Antibody; Pharmacology; 2019-20 coronavirus outbreak; Immunology; Virology; Internal medicine; Tumor necrosis factor alpha; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006659311,0.0002104722,0.0006155782,0.0003000425,0.0001028911,0.0001282986,0.0001193157,0.00009570034,0.000002810295],"category_scores_gemma":[0.0004600444,0.0001602187,0.00009500173,0.0003836587,0.00009797275,0.0001842635,0.0001190348,0.0004127647,0.000001750361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001276258,"about_ca_system_score_gemma":0.0003376136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002310135,"about_ca_topic_score_gemma":0.0004998885,"domain_scores_codex":[0.9976784,0.0004044527,0.000754486,0.0003278997,0.0004797149,0.0003550545],"domain_scores_gemma":[0.9984818,0.0004503683,0.0002522239,0.0002485275,0.0004966236,0.00007048478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01730747,0.0009321999,0.9530245,0.00002819726,0.0001770061,0.003055054,0.00259167,1.349381e-7,0.01758458,0.000002049862,0.00004671846,0.005250443],"study_design_scores_gemma":[0.01343782,0.001344499,0.9442997,0.000349564,0.00009033783,0.0001350712,0.002974498,0.00002228845,0.03505477,0.0001494356,0.001994194,0.0001478024],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966455,0.002403606,0.000002068328,0.0002571016,0.0001415271,0.0003689038,0.00005663999,0.0000136236,0.0001109926],"genre_scores_gemma":[0.9979328,0.0002100142,0.00004671544,0.001584634,0.0001692996,0.00000821999,0.000004882591,0.00001955882,0.00002390266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01747019,"threshold_uncertainty_score":0.6533527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04760928313491763,"score_gpt":0.3720440811111697,"score_spread":0.324434797976252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}