{"id":"W3197016818","doi":"10.1093/ecco-jcc/jjab153","title":"Adalimumab and Infliximab Impair SARS-CoV-2 Antibody Responses: Results from a Therapeutic Drug Monitoring Study in 11 422 Biologic-Treated Patients","year":2021,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Medical Research Council; Crohn's and Colitis UK; Public Health England; National Institute for Health and Care Research; Public Health Wales; Royal Devon and Exeter NHS Foundation Trust","keywords":"Medicine; Adalimumab; Infliximab; Therapeutic drug monitoring; Drug; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Drug holiday; Antibody; Pharmacology; 2019-20 coronavirus outbreak; Immunology; Virology; Internal medicine; Tumor necrosis factor alpha; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005956869,0.000387408,0.0005215235,0.0003567041,0.0004970926,0.000832703,0.000215355,0.0006164011,0.0009412487],"category_scores_gemma":[0.001632924,0.0003155398,0.0003383475,0.00043774,0.0002563205,0.0003551797,0.0002837979,0.0005853759,0.0003511521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004238072,"about_ca_system_score_gemma":0.0002021971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00139459,"about_ca_topic_score_gemma":0.001443231,"domain_scores_codex":[0.9993554,0.0002408098,0.00004913398,0.0001579602,0.0001090272,0.00008779015],"domain_scores_gemma":[0.999,0.0002162345,0.0003565372,0.0000635844,0.00008317594,0.0002805387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003126405,0.0004815495,0.9911934,0.00001567616,0.0000768777,0.000280342,0.0002562636,0.0000495949,0.001274944,0.000009761347,0.0001218133,0.00311337],"study_design_scores_gemma":[0.0001933415,0.001642228,0.9966054,0.000003948267,0.00004637368,0.00066358,0.0001506161,0.0001974221,0.0002232836,0.00000831263,0.0002601654,0.000005247752],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996542,0.00008220123,0.0000158848,0.00001361712,0.000002164489,0.000005908917,0.00006291447,0.000001082073,0.0001621145],"genre_scores_gemma":[0.9995596,0.00004616672,0.00003743083,0.00004068913,0.000009820016,0.00000916952,0.0001917058,9.708565e-7,0.0001044702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00139459,"threshold_uncertainty_score":0.003150344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04760928313491763,"score_gpt":0.3720440811111697,"score_spread":0.324434797976252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}