{"id":"W3197061720","doi":"10.1111/jvh.13608","title":"Farnesoid X receptor agonist for the treatment of chronic hepatitis B: A safety study","year":2021,"lang":"en","type":"article","venue":"Journal of Viral Hepatitis","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Farnesoid X receptor; Medicine; Internal medicine; Entecavir; Placebo; HBsAg; Gastroenterology; Agonist; HBeAg; Pegylated interferon; Hepatitis B; Adverse effect; Hepatitis B virus; Viral load; Partial agonist; Pharmacology; Receptor; Lamivudine; Chronic hepatitis; Immunology; Nuclear receptor; Virus; Biology; Ribavirin; Transcription factor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002047404,0.0007063302,0.001510246,0.0002747392,0.0003524791,0.0005694276,0.0004015019,0.001390072,0.005146027],"category_scores_gemma":[0.001149677,0.0002808829,0.001387482,0.000351409,0.0004697431,0.0005282749,0.0001965436,0.00157294,0.0005833065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003128129,"about_ca_system_score_gemma":0.0008078888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000347193,"about_ca_topic_score_gemma":0.0007131249,"domain_scores_codex":[0.9993258,0.0004091799,0.00005688308,0.00007270532,0.00007845592,0.00005708764],"domain_scores_gemma":[0.9988506,0.0004061603,0.0002608995,0.00007889674,0.000121775,0.0002816163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.831386,0.01693215,0.006756148,0.003181131,0.002745757,0.0003232263,0.0001552469,0.000482991,0.02141398,0.0003304657,0.003099069,0.1131938],"study_design_scores_gemma":[0.7077243,0.2606734,0.02053313,0.0002322369,0.001612307,0.0003779432,0.00005803575,0.0004480477,0.002392392,0.0001755172,0.005746696,0.0000258762],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9633532,0.02497315,0.00106607,0.001004274,0.0002869077,0.002734006,0.002111449,0.00009001472,0.004380943],"genre_scores_gemma":[0.9825832,0.009472033,0.0007886961,0.001558073,0.0006726594,0.001498069,0.001449157,0.00001470435,0.001963383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005146027,"threshold_uncertainty_score":0.01721519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0252325662131755,"score_gpt":0.310246226996691,"score_spread":0.2850136607835155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}