{"id":"W3197093656","doi":"10.3389/fnagi.2021.683783","title":"Altered Spontaneous Brain Activity in Subjects With Different Cognitive States of Biologically Defined Alzheimer's Disease: A Surface-Based Functional Brain Imaging Study","year":2021,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Science Foundation of Zhejiang Province; National Institute on Aging; National Key Research and Development Program of China; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; National Natural Science Foundation of China; Eisai; Zhejiang Provincial Postdoctoral Science Foundation; Genentech; IXICO; Northern California Institute for Research and Education; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Posterior cingulate; Dementia; Neuroimaging; Biomarker; Neuroscience; Brain activity and meditation; Alzheimer's disease; Psychology; Cognition; Clinical Dementia Rating; Medicine; Audiology; Internal medicine; Disease; Electroencephalography; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004094104,0.000392463,0.0003106626,0.0007490266,0.0002710212,0.0004397526,0.0002100747,0.0004478545,0.0006839327],"category_scores_gemma":[0.001179713,0.0001228088,0.0002639566,0.0004580354,0.0004529456,0.0003957434,0.0003129588,0.0002080376,0.0001575109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001475734,"about_ca_system_score_gemma":0.0001488755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001600498,"about_ca_topic_score_gemma":0.001568255,"domain_scores_codex":[0.9998147,0.00003680368,0.00002102311,0.00006800174,0.0000350824,0.00002449405],"domain_scores_gemma":[0.9995062,0.0001146755,0.0001472015,0.00006757722,0.00008152931,0.00008286607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003106502,0.0005913221,0.9647447,0.00006618343,0.0002773161,0.0007411665,0.001000105,0.0002673921,0.01950237,0.00007782956,0.0001080535,0.009516917],"study_design_scores_gemma":[0.0000170038,0.0004236787,0.9982116,0.000001289573,0.00003162424,0.00045683,0.0001604418,0.0002555792,0.0003398693,0.00004438979,0.00005303706,0.000004572322],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996901,0.00003043232,0.0001388014,0.000002815658,0.00000126488,0.000006928913,0.0000560956,0.000002238301,0.00007135099],"genre_scores_gemma":[0.999551,0.00002130347,0.0001433531,0.000006636923,0.000007758566,0.00001176855,0.000207557,0.000001725148,0.00004882817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001600498,"threshold_uncertainty_score":0.003182352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03512378680662705,"score_gpt":0.2622809124564133,"score_spread":0.2271571256497863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}