{"id":"W3197097901","doi":"10.1101/2021.08.27.458001","title":"Zika Virus Induces Mitotic Catastrophe in Human Neural Progenitors by Triggering Unscheduled Mitotic Entry in the Presence of DNA Damage While Functionally Depleting Nuclear PNKP","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Microcephaly; Biology; Zika virus; Mitosis; DNA damage; Cell biology; Mitotic catastrophe; G2-M DNA damage checkpoint; DNA repair; DNA replication; Virology; Genetics; Cell cycle checkpoint; Cell cycle; DNA; Virus; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009069734,0.0002665869,0.0001626413,0.0001457819,0.0001000861,0.0002060811,0.0001937123,0.0001650692,0.001395391],"category_scores_gemma":[0.00006935457,0.0001437203,0.0001597131,0.00008737093,0.0001077713,0.0001033993,0.0001354584,0.0004541423,0.0002738856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002390718,"about_ca_system_score_gemma":0.0001469424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001058945,"about_ca_topic_score_gemma":0.001211182,"domain_scores_codex":[0.9999237,0.00001250888,0.000009462865,0.00001440963,0.00001896802,0.00002097509],"domain_scores_gemma":[0.9999622,0.00001055266,0.000007834557,0.000005400029,0.000004216945,0.000009803885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000178437,0.00004020141,0.0001313968,0.00005783287,0.000005833175,0.00004298278,0.00001208979,0.00005199171,0.9985223,0.0000881724,0.00005150128,0.0008172029],"study_design_scores_gemma":[0.0000402659,0.0005814795,0.003452623,0.000006182094,0.00001082753,0.0001890196,0.00001270139,0.00113615,0.9930729,0.00003022973,0.001465024,0.000002716302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944865,0.002090125,0.001182673,0.00004948785,0.0000301,0.00004621369,0.0004367452,0.00006282048,0.001615262],"genre_scores_gemma":[0.9956865,0.0008125467,0.001028089,0.00002150431,0.000006174452,0.00004338323,0.0006639722,0.00000800143,0.001729732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001395391,"threshold_uncertainty_score":0.004668117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01282727649913033,"score_gpt":0.2253530303022295,"score_spread":0.2125257538030992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}