{"id":"W3197122623","doi":"10.1101/2021.08.30.457716","title":"KMT2D-NOTCH Mediates Coronary Abnormalities in Hypoplastic Left Heart Syndrome","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of Washington; National Institute of Child Health and Human Development; Heart and Stroke Foundation of Canada","keywords":"Hypoplastic left heart syndrome; Ventricle; Internal medicine; Cardiology; Medicine; Notch signaling pathway; Heart disease; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000736808,0.0002853685,0.0001398909,0.0003043219,0.000104511,0.0001366491,0.0001391793,0.0002595106,0.00235191],"category_scores_gemma":[0.0001369282,0.00008576969,0.0001882322,0.0001255988,0.0001790474,0.00006955672,0.0002216711,0.0002618613,0.0002548054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001106407,"about_ca_system_score_gemma":0.00008063063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003765178,"about_ca_topic_score_gemma":0.0004567291,"domain_scores_codex":[0.9999228,0.0000139827,0.00001036609,0.00002226291,0.00001904896,0.00001160007],"domain_scores_gemma":[0.99993,0.00001364038,0.00002610588,0.000005431862,0.000004344188,0.0000205009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002157955,0.00003451161,0.01295508,0.00004633454,0.00002752014,0.006360807,0.00006758643,0.0002397829,0.9757429,0.0002623874,0.0002047859,0.003842528],"study_design_scores_gemma":[0.0001464244,0.0005445598,0.3641325,0.00007055546,0.0001909508,0.06625881,0.0004486778,0.008547558,0.5513995,0.0007357887,0.007496296,0.00002832541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979014,0.0002330733,0.0008964122,0.00003822478,0.000008844232,0.00000813695,0.0003346501,0.00002527631,0.0005539681],"genre_scores_gemma":[0.9988951,0.0000981236,0.0002873147,0.0000338076,0.000004599559,0.000006396863,0.0002701624,0.000007285159,0.0003971676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00235191,"threshold_uncertainty_score":0.007867932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01160094239398488,"score_gpt":0.2349063630585362,"score_spread":0.2233054206645513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}