{"id":"W3197133949","doi":"10.3390/cancers13174444","title":"Normalizing Tumor Vasculature to Reduce Hypoxia, Enhance Perfusion, and Optimize Therapy Uptake","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Angiogenesis; Hypoxia (environmental); Cancer research; Tumor microenvironment; Tumor hypoxia; Medicine; Metastasis; Lymphatic system; Immunotherapy; Carcinogenesis; Pathology; Immunology; Immune system; Cancer; Radiation therapy; Tumor cells; Internal medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001595704,0.0004577571,0.0009106394,0.00005438559,0.0001290191,0.00006243822,0.0002934808,0.0003428372,0.0001165746],"category_scores_gemma":[0.00004258022,0.0003889548,0.0005130247,0.0002248093,0.00006980555,0.000004020214,0.0001780852,0.000181827,0.000008205692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002169256,"about_ca_system_score_gemma":0.001239259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004295506,"about_ca_topic_score_gemma":0.00001885258,"domain_scores_codex":[0.9981607,0.00008236982,0.0003527617,0.0008740498,0.0001588749,0.0003712653],"domain_scores_gemma":[0.9988765,0.00001371876,0.0001734964,0.0006075062,0.0001307645,0.0001980898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002127497,0.000006555751,0.000001454335,0.000729873,0.000230491,0.00001231799,0.00004137675,0.00007972251,0.00241111,0.000007760847,0.01770091,0.9787571],"study_design_scores_gemma":[0.0001580359,0.00007789374,0.000004615337,0.002159016,0.0001331665,0.00005029708,0.0000345198,0.000002094238,0.002265879,5.916736e-7,0.9946311,0.0004828662],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001309526,0.9969512,0.0001107791,0.00002733512,0.000565085,0.0004815904,0.00006989815,0.00001253853,0.0004720776],"genre_scores_gemma":[0.00008648597,0.9948096,0.001233235,0.0007747237,0.001064257,0.0002624772,0.0001885097,0.00009206054,0.001488691],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9782743,"threshold_uncertainty_score":0.9998562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02841079800870965,"score_gpt":0.3229959157344465,"score_spread":0.2945851177257369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}