{"id":"W3197156699","doi":"10.1016/j.biopsych.2021.05.029","title":"Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors","year":2021,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Suicide and Self-Harm Studies","field":"Psychology","cited_by":247,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; University of Toronto; University Health Network; Dalhousie University; Hospital for Sick Children; Centre for Addiction and Mental Health","funders":"Cilag; National Institute on Alcohol Abuse and Alcoholism; Statens Serum Institut; Instituto de Salud Carlos III; NIHR Maudsley Biomedical Research Centre; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Campbell Family Mental Health Research Institute; Veterans Affairs San Diego Healthcare System; Université de Paris; Neuraxpharm; Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición; Medical Research Council; Servier; Universitat Autònoma de Barcelona; Diakonhjemmet; H. Lundbeck A/S; Hospital for Sick Children; Division of Materials Research; Centre National de la Recherche Scientifique; Universitat de Barcelona; Université Paris Diderot; Universitetet i Oslo; School of Medicine; Universidade Federal do Rio Grande do Sul; Umeå Universitet; National Center for Advancing Translational Sciences; Kaiser Permanente; Saint Petersburg State University; Centre Hospitalier Universitaire Vaudois; College of Engineering, Michigan State University; Dalhousie University; VA Pittsburgh Healthcare System; State University of New York; Queensland University of Technology; Institut National de la Santé et de la Recherche Médicale; Gentofte Hospital; National Institute for Health and Care Research; Fresenius Medical Care North America; U.S. Department of Veterans Affairs; GW Pharmaceuticals; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; ACADIA Pharmaceuticals; Emory University; Jazz Pharmaceuticals; Wellcome Trust; Sunovion; Indivior; Aarhus Universitet; National Institute of Mental Health; Hospital de Clínicas de Porto Alegre; Université de Lausanne; Lundbeckfonden; Eli Lilly and Company; King Abdullah University of Science and Technology; Vanderbilt University; Karolinska Institutet; National Institute of General Medical Sciences; National Alliance for Research on Schizophrenia and Depression; Florida State University; American Society of Clinical Psychopharmacology; Michigan State University; State University of New York Upstate Medical University; Pfizer; Brain and Behavior Research Foundation; National Institutes of Health; Syracuse University; Universidade de Coimbra; University of Toronto","keywords":"Genetic architecture; Psychiatry; Psychology; Medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001594181,0.0005196648,0.0004530697,0.001893314,0.0007011136,0.001129581,0.0007469403,0.000802509,0.002201379],"category_scores_gemma":[0.004013801,0.0003426129,0.0008840915,0.001212267,0.001006304,0.0006346291,0.001108927,0.0009047088,0.0001242788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003117488,"about_ca_system_score_gemma":0.000597689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004613357,"about_ca_topic_score_gemma":0.007255407,"domain_scores_codex":[0.9982828,0.0008102304,0.0001322531,0.0003871135,0.0002125196,0.0001751937],"domain_scores_gemma":[0.9971793,0.001262276,0.0005203656,0.0005237911,0.0002584518,0.0002559441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004365985,0.0001234034,0.9761807,0.00005252061,0.001897013,0.001078074,0.001051079,0.000201378,0.00866967,0.001259178,0.0001406093,0.008909884],"study_design_scores_gemma":[0.00002063105,0.0001513576,0.9939814,0.00003263716,0.0005529588,0.001115813,0.00103652,0.0006285319,0.0006298883,0.001546584,0.0002908497,0.00001263475],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963748,0.00109121,0.001027705,0.0003606012,0.00001999583,0.000008736615,0.0001158375,0.000007939583,0.0009932286],"genre_scores_gemma":[0.9988274,0.00026229,0.0005257407,0.0000645514,0.00002008627,0.000004565614,0.00007327416,0.000005383273,0.0002165574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004613357,"threshold_uncertainty_score":0.009173036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02962423490920971,"score_gpt":0.2977922599737521,"score_spread":0.2681680250645424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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