{"id":"W3197167619","doi":"10.1111/hae.14398","title":"Low immunogenicity of emicizumab in persons with haemophilia A","year":2021,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"Chugai Pharmaceutical; F. Hoffmann-La Roche","keywords":"Immunogenicity; Medicine; Haemophilia A; Haemophilia; Virology; Pediatrics; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002194329,0.0002587978,0.000671956,0.0002500378,0.00006996841,0.00001526269,0.0001490453,0.0001732758,0.0006083885],"category_scores_gemma":[0.000145579,0.0001983585,0.0001991068,0.0009398665,0.0002665004,0.00008905662,0.000099492,0.0004195971,0.00007084701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001894438,"about_ca_system_score_gemma":0.000726793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001112364,"about_ca_topic_score_gemma":0.0001624214,"domain_scores_codex":[0.9978814,0.00009168995,0.0004062655,0.0004910381,0.0005949131,0.0005346723],"domain_scores_gemma":[0.9986305,0.00009172224,0.00007796718,0.0007245926,0.0002692387,0.0002059263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005178557,0.005712514,0.5685171,0.001770303,0.001120791,0.01838324,0.004596058,0.00006009377,0.3696786,0.00106373,0.00265752,0.02126144],"study_design_scores_gemma":[0.01588543,0.001754387,0.2637023,0.002019327,0.0003387846,0.002556358,0.001854867,0.0005060936,0.708465,0.0006733768,0.001559972,0.0006840641],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889982,0.001222222,0.00001397263,0.002445921,0.00006926069,0.0004756487,0.00003329596,0.00004490183,0.006696574],"genre_scores_gemma":[0.9938353,0.0002036095,0.0008355684,0.0001448051,0.00008392718,0.00003179367,0.00007629019,0.00004208978,0.004746592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3387864,"threshold_uncertainty_score":0.8088824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02226104183162267,"score_gpt":0.2882021090722536,"score_spread":0.2659410672406309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}