{"id":"W3197167619","doi":"10.1111/hae.14398","title":"Low immunogenicity of emicizumab in persons with haemophilia A","year":2021,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"Chugai Pharmaceutical; F. Hoffmann-La Roche","keywords":"Immunogenicity; Medicine; Haemophilia A; Haemophilia; Virology; Pediatrics; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002043717,0.0002291883,0.0003842031,0.000295991,0.0001836035,0.0003634071,0.0001327622,0.0003020888,0.001510562],"category_scores_gemma":[0.004181731,0.0001012345,0.0003276311,0.0002202253,0.0001285372,0.0002740685,0.0001590458,0.0003116157,0.000223756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001908734,"about_ca_system_score_gemma":0.0001311015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003181002,"about_ca_topic_score_gemma":0.0002283592,"domain_scores_codex":[0.9992021,0.0003961134,0.00008078937,0.00008741497,0.0001756335,0.00005807115],"domain_scores_gemma":[0.9982943,0.0005951615,0.0007650935,0.00007731638,0.0001689568,0.00009913758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005971715,0.0004470308,0.8753995,0.0004900107,0.0006615727,0.0007175936,0.0003136406,0.0003174085,0.01412098,0.00009331045,0.0007480454,0.1007192],"study_design_scores_gemma":[0.0001437245,0.005375052,0.9878215,0.0000643042,0.0002828311,0.002234418,0.00008033842,0.000329297,0.002205283,0.0000637901,0.001394585,0.000004855012],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963097,0.002345704,0.000265058,0.00007541316,0.000008863562,0.00002293177,0.00007807842,0.000006032578,0.0008881246],"genre_scores_gemma":[0.9995179,0.0001976239,0.00008841448,0.00003409478,0.00001493908,0.000008588753,0.00005715876,0.000001000948,0.0000803417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002043717,"threshold_uncertainty_score":0.01080829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02226104183162267,"score_gpt":0.2882021090722536,"score_spread":0.2659410672406309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}