{"id":"W3197181042","doi":"10.1124/molpharm.121.000301","title":"Therapeutic Neuroprotection by an Engineered Neurotrophin that Selectively Activates Tropomyosin Receptor Kinase (Trk) Family Neurotrophin Receptors but Not the p75 Neurotrophin Receptor","year":2021,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital; Simon Fraser University","funders":"Canadian Institutes of Health Research; Consortium canadien en neurodégénérescence associée au vieillissement; U.S. Department of Defense","keywords":"Trk receptor; Tropomyosin receptor kinase A; Neurotrophin; Low-affinity nerve growth factor receptor; Tropomyosin receptor kinase C; Tropomyosin receptor kinase B; Neuroprotection; Biology; Nerve growth factor; Cell biology; Receptor; Neurotrophic factors; Neuroscience; Growth factor; Biochemistry; Platelet-derived growth factor receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009090619,0.0004580991,0.000253567,0.0001801824,0.0001664939,0.0002497297,0.0001900016,0.0003282806,0.0009762867],"category_scores_gemma":[0.00005523857,0.0001073285,0.0002028977,0.0001382661,0.0001973489,0.0001973989,0.0001131749,0.0004558607,0.0001840975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003037259,"about_ca_system_score_gemma":0.0003608843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009742963,"about_ca_topic_score_gemma":0.002230016,"domain_scores_codex":[0.999934,0.000005593556,0.000003741919,0.00001417437,0.00001558656,0.00002690954],"domain_scores_gemma":[0.9999735,0.00000374013,0.00001013862,0.000002344834,0.000003078543,0.000007094474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001975102,0.00004873736,0.00003834564,0.00002242619,0.000007846751,0.00005556615,0.00001128901,0.0001273554,0.9975285,0.0002363246,0.00004802241,0.001678175],"study_design_scores_gemma":[0.00007227449,0.0009199806,0.0009731728,0.00000555244,0.00003820031,0.0002965637,0.00001674188,0.0006765286,0.9949275,0.00007581622,0.001991473,0.000006200761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934852,0.0008363326,0.003389336,0.00009117486,0.00006898517,0.00004444241,0.0001562053,0.00007937918,0.001849066],"genre_scores_gemma":[0.9941396,0.0007480746,0.002779595,0.00004333491,0.00001040294,0.00002745518,0.0001427734,0.00001500351,0.002093839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009762867,"threshold_uncertainty_score":0.003266037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03052795957162173,"score_gpt":0.2769806904323817,"score_spread":0.2464527308607599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}