{"id":"W3197206719","doi":"10.3389/fbinf.2021.690769","title":"Mutation Edgotype Drives Fitness Effect in Human","year":2021,"lang":"en","type":"article","venue":"Frontiers in Bioinformatics","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; McGill University","keywords":"Interactome; Missense mutation; Biology; Genetics; Mutation; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001871311,0.0003599928,0.0002352681,0.0004557252,0.0001657751,0.000291262,0.0001926839,0.000309271,0.001062133],"category_scores_gemma":[0.000952224,0.000121331,0.0003316951,0.0003834493,0.0002756066,0.0001602898,0.0002892712,0.0001819059,0.0002178489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002540338,"about_ca_system_score_gemma":0.000125216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001328732,"about_ca_topic_score_gemma":0.001448821,"domain_scores_codex":[0.99983,0.00003041084,0.00001051354,0.00006790939,0.00004649139,0.00001471537],"domain_scores_gemma":[0.9997254,0.0001109211,0.00007413749,0.00003171494,0.00003293972,0.00002493195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001007823,0.0001533698,0.3595724,0.0002748181,0.0004651936,0.002216918,0.0001569986,0.1183753,0.4763588,0.004226144,0.0009622633,0.03622989],"study_design_scores_gemma":[0.00005456703,0.0006713591,0.5390463,0.00003609723,0.0002278569,0.007949822,0.0002257571,0.2824004,0.1602993,0.004994745,0.004022469,0.00007141379],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946048,0.0001412116,0.003992344,0.00002348316,0.00000357637,0.000006485426,0.0003516283,0.0000924453,0.0007840604],"genre_scores_gemma":[0.9973903,0.00006192995,0.001845954,0.00002094665,0.000001305644,0.000004472162,0.0005012125,0.00001599482,0.0001578405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001328732,"threshold_uncertainty_score":0.003553152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004234037600124879,"score_gpt":0.2263624174473527,"score_spread":0.2221283798472278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}