{"id":"W3197206719","doi":"10.3389/fbinf.2021.690769","title":"Mutation Edgotype Drives Fitness Effect in Human","year":2021,"lang":"en","type":"article","venue":"Frontiers in Bioinformatics","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; McGill University","keywords":"Interactome; Missense mutation; Biology; Genetics; Mutation; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029731,0.0001653132,0.00022913,0.0001190346,0.00005529183,0.00004628558,0.0001689668,0.0002214657,0.000009659177],"category_scores_gemma":[0.00005450006,0.0001653905,0.00006736186,0.0002413965,0.00006481359,0.00001755872,0.0001068511,0.0001652514,0.00000777546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004846777,"about_ca_system_score_gemma":0.00007566713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005425607,"about_ca_topic_score_gemma":0.00005950624,"domain_scores_codex":[0.998921,0.00004676086,0.0004808467,0.0001434056,0.0001129565,0.0002949859],"domain_scores_gemma":[0.99947,0.00001030799,0.000115182,0.0003054044,0.0000431107,0.00005597589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0005184407,0.0006313664,0.3968181,0.002227791,0.0004534983,0.0002478976,0.009415598,0.02581581,0.03128854,0.002351688,0.1742982,0.3559331],"study_design_scores_gemma":[0.02294786,0.002708092,0.09732583,0.001188226,0.0001782899,0.0002769602,0.01387454,0.4717202,0.2901281,0.01900657,0.07571748,0.004927808],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9262296,0.001206572,0.0607875,0.00009922704,0.001149958,0.0003790156,0.00001787068,0.00001830099,0.01011195],"genre_scores_gemma":[0.9540836,0.0002478355,0.04361535,0.0004557051,0.0001477836,0.00003018073,0.0008159598,0.00002529057,0.0005782741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4459044,"threshold_uncertainty_score":0.6744429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004234037600124879,"score_gpt":0.2263624174473527,"score_spread":0.2221283798472278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}