{"id":"W3197214880","doi":"10.3390/proteomes9030038","title":"Proteomes Are of Proteoforms: Embracing the Complexity","year":2021,"lang":"en","type":"review","venue":"Proteomes","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Proteome; Computational biology; Computer science; Data science; Human proteome project; Genome; Biology; Bioinformatics; Proteomics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001820664,0.001373251,0.001838638,0.002331266,0.0006426834,0.003593594,0.0013825,0.001795516,0.002474721],"category_scores_gemma":[0.001610375,0.0005101752,0.0005935873,0.002714889,0.003393895,0.008547895,0.001859556,0.006396825,0.003277353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001572359,"about_ca_system_score_gemma":0.001541367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008548443,"about_ca_topic_score_gemma":0.0009674642,"domain_scores_codex":[0.9990669,0.0002059617,0.00006976319,0.0001811839,0.000418943,0.00005715428],"domain_scores_gemma":[0.9986956,0.0006692144,0.0001155254,0.00008956611,0.0003409688,0.00008921854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008053807,0.00006007068,0.0003405947,0.01414491,0.0001275604,0.0002553784,0.0003286995,0.0006802153,0.01348663,0.09145113,0.06993275,0.8091115],"study_design_scores_gemma":[0.00000338405,0.00003509059,0.0003711141,0.001430436,0.0000249276,0.0005833564,0.0001412097,0.0001302672,0.001540223,0.02427248,0.9714415,0.00002602206],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001507952,0.9922343,0.001392413,0.003016422,0.000750283,0.000004735016,0.00002498232,0.00003637056,0.002389633],"genre_scores_gemma":[0.001497442,0.9932824,0.001522626,0.001389583,0.000821065,0.000009805578,0.00003643482,0.00001420695,0.001426367],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003593594,"threshold_uncertainty_score":0.01140827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0969464571629138,"score_gpt":0.3655386628919381,"score_spread":0.2685922057290244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}