{"id":"W3197214880","doi":"10.3390/proteomes9030038","title":"Proteomes Are of Proteoforms: Embracing the Complexity","year":2021,"lang":"en","type":"review","venue":"Proteomes","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Proteome; Computational biology; Computer science; Data science; Human proteome project; Genome; Biology; Bioinformatics; Proteomics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000341793,0.0006603253,0.002110215,0.0000891056,0.0003517165,0.00008699676,0.001153819,0.0004598734,0.001640793],"category_scores_gemma":[0.0002057563,0.000424012,0.0007996126,0.0004397679,0.0005059284,0.0001001867,0.0005919033,0.00111815,0.00005625969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001508485,"about_ca_system_score_gemma":0.0003434689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001972404,"about_ca_topic_score_gemma":0.000002099587,"domain_scores_codex":[0.9971512,0.00008007087,0.00114807,0.0007201778,0.0003986584,0.0005018343],"domain_scores_gemma":[0.9960784,0.0001401792,0.001846439,0.001621845,0.0002201582,0.0000929357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000004435968,0.0001919394,0.00001057665,0.07891748,0.0003553384,0.00001064731,0.0001109749,0.000002001069,0.0002663733,0.01587477,0.0003815039,0.903874],"study_design_scores_gemma":[0.0001056351,0.000014659,6.946657e-7,0.02201689,0.0002876893,0.00004443618,0.0001057998,0.000006120662,0.01026188,0.01034944,0.9562237,0.0005830391],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001478465,0.9877273,0.002315255,0.0001368048,0.0000227425,0.004980337,0.0003549197,0.0002636924,0.004184101],"genre_scores_gemma":[0.00002191489,0.9565493,0.02533177,0.00001748337,0.0002359095,0.01640922,0.0001810316,0.0001353508,0.001118049],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9558422,"threshold_uncertainty_score":0.9998212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0969464571629138,"score_gpt":0.3655386628919381,"score_spread":0.2685922057290244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}