{"id":"W3197222415","doi":"10.1186/s13063-021-05664-0","title":"A trial platform to assess approved SARS-CoV-2 vaccines in immunocompromised patients: first sub-protocol for a pilot trial comparing the mRNA vaccines Comirnaty® and COVID-19 mRNA Vaccine Moderna®","year":2021,"lang":"en","type":"article","venue":"Trials","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"Universitätsspital Zürich; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Bern; Inselspital, Universitätsspital Bern; Swiss Transplant Cohort Study; Universitätsspital Basel; Universität Basel; National Science Foundation","keywords":"Medicine; Clinical trial; Randomized controlled trial; Pandemic; Cohort; Vaccine efficacy; Vaccination; Vaccine trial; Protocol (science); Coronavirus disease 2019 (COVID-19); Internal medicine; Immunology; Disease; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02442229,0.003808629,0.004024389,0.000971584,0.002107218,0.002066447,0.001941909,0.006167357,0.04441584],"category_scores_gemma":[0.02485135,0.001589351,0.00333148,0.0008783077,0.002135156,0.002542834,0.001989449,0.005878131,0.009859785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002278869,"about_ca_system_score_gemma":0.01089967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007182912,"about_ca_topic_score_gemma":0.001601086,"domain_scores_codex":[0.9884095,0.007861521,0.001006257,0.0009187573,0.0006440219,0.001159846],"domain_scores_gemma":[0.9840103,0.004712116,0.003155769,0.002273323,0.002804458,0.003044013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8925922,0.02121093,0.00138741,0.009620165,0.001379097,0.0003668275,0.0004242287,0.002105749,0.004903485,0.003056777,0.02161643,0.04133664],"study_design_scores_gemma":[0.8290976,0.1157861,0.003636375,0.001798977,0.0006383546,0.000127391,0.0001351016,0.001467196,0.001717529,0.002777012,0.04272335,0.00009494614],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01011395,0.0003760323,0.002916666,0.0005855141,0.0005844081,0.9815828,0.001791261,0.0001555892,0.001893855],"genre_scores_gemma":[0.009080508,0.0001504682,0.003411919,0.0005307327,0.0001446896,0.9856273,0.0003508742,0.00001181156,0.0006916266],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.04441584,"threshold_uncertainty_score":0.1485857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3457444301149712,"score_gpt":0.4694370772944464,"score_spread":0.1236926471794752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}