{"id":"W3197222415","doi":"10.1186/s13063-021-05664-0","title":"A trial platform to assess approved SARS-CoV-2 vaccines in immunocompromised patients: first sub-protocol for a pilot trial comparing the mRNA vaccines Comirnaty® and COVID-19 mRNA Vaccine Moderna®","year":2021,"lang":"en","type":"article","venue":"Trials","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"Universitätsspital Zürich; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Bern; Inselspital, Universitätsspital Bern; Swiss Transplant Cohort Study; Universitätsspital Basel; Universität Basel; National Science Foundation","keywords":"Medicine; Clinical trial; Randomized controlled trial; Pandemic; Cohort; Vaccine efficacy; Vaccination; Vaccine trial; Protocol (science); Coronavirus disease 2019 (COVID-19); Internal medicine; Immunology; Disease; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006649893,0.0007405866,0.002992013,0.0005797558,0.00050958,0.0004479288,0.0007412438,0.0003026158,0.00002644086],"category_scores_gemma":[0.02413864,0.0005192889,0.0005463168,0.001028152,0.00005302936,0.0002726856,0.0005110112,0.0006643498,0.00001750399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005477623,"about_ca_system_score_gemma":0.001492303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001395549,"about_ca_topic_score_gemma":0.002621436,"domain_scores_codex":[0.9930927,0.0008102933,0.002882695,0.001197484,0.0009544308,0.001062412],"domain_scores_gemma":[0.9908414,0.006081183,0.0008242861,0.001220288,0.0008057031,0.0002271807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9093023,0.002647632,0.005691879,0.0008200704,0.0004437216,0.000046875,0.0005025049,0.00001822342,0.07207774,0.0001441523,0.006606884,0.001698015],"study_design_scores_gemma":[0.7879463,0.005376576,0.001337144,0.0002956707,0.0002420825,0.00001805295,0.0001660437,0.002801039,0.1117264,0.0009070187,0.08860952,0.0005740871],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.738282,0.00009914986,0.0005169169,0.002175865,0.0006549864,0.2578403,0.00004915757,0.0001306577,0.0002510196],"genre_scores_gemma":[0.4856026,0.00001648446,0.0007257798,0.02580877,0.003413097,0.4840752,0.00007761632,0.0002199464,0.00006046724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2526794,"threshold_uncertainty_score":0.9997259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3457444301149712,"score_gpt":0.4694370772944464,"score_spread":0.1236926471794752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}