{"id":"W3197227866","doi":"10.1002/stem.3453","title":"The Cyclin-Like Protein <scp>SPY1</scp> Overrides Reprogramming Induced Senescence Through <scp>EZH2</scp> Mediated <scp>H3K27me3</scp>","year":2021,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Biology; Reprogramming; Cell biology; Induced pluripotent stem cell; Stem cell; Cell Cycle Protein; Cell cycle; Cyclin; Embryonic stem cell; Cancer research; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001735337,0.0009455537,0.0008167133,0.000127828,0.0008984716,0.0005884753,0.001630821,0.0009996863,0.000009877444],"category_scores_gemma":[0.00214583,0.0008148323,0.0005570427,0.001114073,0.0004905763,0.00006020632,0.001463526,0.001102921,0.0004793365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001485344,"about_ca_system_score_gemma":0.0008961347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001621134,"about_ca_topic_score_gemma":0.0002017599,"domain_scores_codex":[0.9915223,0.001019302,0.001241937,0.002268204,0.001553801,0.00239444],"domain_scores_gemma":[0.9938805,0.001430879,0.0006609884,0.002593115,0.0008286549,0.0006058522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009760926,0.0002641918,0.001062359,0.0002475929,0.0003153906,0.0003124505,0.000519952,0.00004633166,0.982886,0.00008957071,0.01225262,0.001993747],"study_design_scores_gemma":[0.0008851207,0.0002665934,0.0003699353,0.0001466908,0.00005087872,0.0000700921,0.003256796,0.0001236776,0.7309607,0.00009596205,0.2636578,0.000115769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772504,0.007694351,0.0005400818,0.0002142661,0.001204067,0.002039952,0.0001191111,0.0001970017,0.01074079],"genre_scores_gemma":[0.9390494,0.003310775,0.00147734,0.0005685891,0.0009697069,0.0005318461,0.0004732681,0.0003000419,0.05331909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2519254,"threshold_uncertainty_score":0.9994302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02137818979032859,"score_gpt":0.2650828008913754,"score_spread":0.2437046111010469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}