{"id":"W3197227866","doi":"10.1002/stem.3453","title":"The Cyclin-Like Protein <scp>SPY1</scp> Overrides Reprogramming Induced Senescence Through <scp>EZH2</scp> Mediated <scp>H3K27me3</scp>","year":2021,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Biology; Reprogramming; Cell biology; Induced pluripotent stem cell; Stem cell; Cell Cycle Protein; Cell cycle; Cyclin; Embryonic stem cell; Cancer research; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001115859,0.0002544064,0.0001786032,0.0001918916,0.0001443497,0.000229739,0.0001535785,0.00018654,0.002408778],"category_scores_gemma":[0.0001004636,0.00008708712,0.0001527814,0.0001345892,0.0002702526,0.0001988251,0.0002578925,0.0003937223,0.0004595932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002276677,"about_ca_system_score_gemma":0.0002263396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003299935,"about_ca_topic_score_gemma":0.0007885334,"domain_scores_codex":[0.9999238,0.000008276715,0.000005450702,0.00002204356,0.00002487578,0.00001551017],"domain_scores_gemma":[0.9999247,0.00001463576,0.00002396329,0.000009797237,0.00000632255,0.00002062414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003120706,0.000005106364,0.0001385004,0.0000165796,0.000002472813,0.0000384671,0.000004604846,0.00003392574,0.9983405,0.0001555832,0.00003247851,0.001200581],"study_design_scores_gemma":[0.000004544513,0.00004632018,0.001585642,0.000001285161,0.000004201909,0.0001648943,0.000007640866,0.0003248737,0.9960464,0.00003793487,0.001775057,0.000001301035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848779,0.001459409,0.009205407,0.0001769015,0.00003589287,0.0000234512,0.0005017332,0.00016606,0.003553211],"genre_scores_gemma":[0.9934449,0.0004681514,0.002139818,0.00004299272,0.000008510266,0.00001543659,0.0004838621,0.00004540174,0.003350947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002408778,"threshold_uncertainty_score":0.008058131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02137818979032859,"score_gpt":0.2650828008913754,"score_spread":0.2437046111010469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}