{"id":"W3197249571","doi":"10.1016/j.stem.2021.08.001","title":"Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models","year":2021,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":false,"ca_institutions":"Heart and Stroke Foundation; Toronto Rehabilitation Institute; University of Toronto; Toronto General Hospital; University Health Network","funders":"Canadian Institutes of Health Research; Ontario Institute for Regenerative Medicine; University of Toronto; Canada First Research Excellence Fund; Ontario Ministry of Research, Innovation and Science; Juvenile Diabetes Research Foundation United States of America; Juvenile Diabetes Research Foundation Canada; Canada Research Chairs; R. Howard Webster Foundation; Natural Sciences and Engineering Research Council of Canada; Toronto General and Western Hospital Foundation","keywords":"Islet; Embryonic stem cell; Biology; Progenitor cell; Economic shortage; Transplantation; Immunosuppression; Pancreatic islets; Type 1 diabetes; Diabetes mellitus; Regenerative medicine; Pancreas; Stem cell; Immunology; Internal medicine; Endocrinology; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001958031,0.0001817213,0.0004819613,0.00008259667,0.00005440176,0.00001884857,0.00003060741,0.00009304186,0.0001611318],"category_scores_gemma":[0.000009387389,0.0001652413,0.00006310254,0.0001340896,0.00009653365,0.00007298866,0.00005294992,0.0001082632,0.000005995143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004589164,"about_ca_system_score_gemma":0.00009867446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002127707,"about_ca_topic_score_gemma":0.000001937459,"domain_scores_codex":[0.9987651,0.00008085444,0.0003772988,0.0003512531,0.000185052,0.0002404446],"domain_scores_gemma":[0.9992772,0.0001300396,0.000104316,0.0002287671,0.00009685262,0.0001627657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003224714,0.0004164009,0.1155587,0.001132442,0.00004802988,0.00001989899,0.0004685948,0.000005056518,0.8816968,0.00004868695,0.0002091629,0.000363909],"study_design_scores_gemma":[0.002470444,0.0002883514,0.0278187,0.0001173669,0.0001776097,0.000006205124,0.000816111,0.0002283242,0.9672738,0.0002653642,0.0003777881,0.0001599199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876219,0.00301973,0.00001390006,0.00006680338,0.00007695652,0.0003537729,0.00001453875,0.00002416309,0.008808229],"genre_scores_gemma":[0.9960911,0.0001533317,0.0002340297,0.0001816546,0.00003528274,0.00003854489,0.00005949413,0.00001876367,0.003187752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08774004,"threshold_uncertainty_score":0.6738344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01933232197739828,"score_gpt":0.2288888332771006,"score_spread":0.2095565112997023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}