{"id":"W3197249571","doi":"10.1016/j.stem.2021.08.001","title":"Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models","year":2021,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":false,"ca_institutions":"Heart and Stroke Foundation; Toronto Rehabilitation Institute; University of Toronto; Toronto General Hospital; University Health Network","funders":"Canadian Institutes of Health Research; Ontario Institute for Regenerative Medicine; University of Toronto; Canada First Research Excellence Fund; Ontario Ministry of Research, Innovation and Science; Juvenile Diabetes Research Foundation United States of America; Juvenile Diabetes Research Foundation Canada; Canada Research Chairs; R. Howard Webster Foundation; Natural Sciences and Engineering Research Council of Canada; Toronto General and Western Hospital Foundation","keywords":"Islet; Embryonic stem cell; Biology; Progenitor cell; Economic shortage; Transplantation; Immunosuppression; Pancreatic islets; Type 1 diabetes; Diabetes mellitus; Regenerative medicine; Pancreas; Stem cell; Immunology; Internal medicine; Endocrinology; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002620983,0.0001256002,0.0001190295,0.0002151754,0.0001189447,0.0003228342,0.0001140416,0.0001557385,0.001221639],"category_scores_gemma":[0.0002222421,0.00007364539,0.0001485067,0.0001246959,0.0001010419,0.000247284,0.0002540253,0.0003306315,0.0001295114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001751435,"about_ca_system_score_gemma":0.0001596532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007644031,"about_ca_topic_score_gemma":0.00088715,"domain_scores_codex":[0.999894,0.00002106672,0.000007933498,0.00001620557,0.00002675869,0.00003401448],"domain_scores_gemma":[0.9998919,0.00002805693,0.00001892274,0.00001253,0.00001348994,0.00003515199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004378679,0.0001299075,0.001430158,0.00005064948,0.00001315928,0.0001040003,0.0000727488,0.0002898372,0.9905319,0.0006800158,0.0001897092,0.006070171],"study_design_scores_gemma":[0.00004014887,0.0005210121,0.02002908,0.00002721831,0.00007145374,0.0003419035,0.0001318204,0.003032421,0.9678375,0.0002837974,0.007676197,0.000007538181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962462,0.0006441108,0.001519357,0.00004776031,0.00002211617,0.00001279451,0.0001405956,0.00002626109,0.001340875],"genre_scores_gemma":[0.9969295,0.00035551,0.0009139891,0.00002319494,0.000008058867,0.00001207281,0.0003786261,0.00001376739,0.001365256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001221639,"threshold_uncertainty_score":0.004086733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01933232197739828,"score_gpt":0.2288888332771006,"score_spread":0.2095565112997023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}