{"id":"W3197255024","doi":"10.1097/pai.0000000000000969","title":"Molecular Analysis of an Intestinal Neuroendocrine/Non-neuroendocrine Neoplasm (MiNEN) Reveals MLH1 Methylation-driven Microsatellite Instability and a Monoclonal Origin: Diagnostic and Clinical Implications","year":2021,"lang":"en","type":"article","venue":"Applied immunohistochemistry & molecular morphology","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"","keywords":"Microsatellite instability; MLH1; Neoplasm; Neuroendocrine tumors; Microsatellite; Gene; Monoclonal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001368,0.0002484875,0.0001515159,0.0005078754,0.0001422606,0.0002579299,0.0001604324,0.0004346531,0.00101719],"category_scores_gemma":[0.0004471626,0.0001365136,0.0001348677,0.0001673901,0.0002058064,0.0002743456,0.0002317151,0.0002568763,0.0003141503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001243217,"about_ca_system_score_gemma":0.00007464693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002216227,"about_ca_topic_score_gemma":0.0005571151,"domain_scores_codex":[0.9999325,0.000009217981,0.000009544528,0.00001823163,0.00001593498,0.0000144516],"domain_scores_gemma":[0.9997916,0.00006738051,0.00004880216,0.00001757662,0.00002269684,0.00005207294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005142813,0.0000617794,0.2812881,0.0002095789,0.00006602228,0.2848453,0.0003151159,0.0003586439,0.4026182,0.000429772,0.0005883066,0.02870482],"study_design_scores_gemma":[0.00001965516,0.0003838575,0.2155982,0.00003962402,0.0001115583,0.6980413,0.0004871241,0.002435252,0.07666787,0.0004764617,0.005718318,0.00002078102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954529,0.001508347,0.001590555,0.0002216011,0.0000160781,0.0000142091,0.0001086765,0.00003394246,0.001053757],"genre_scores_gemma":[0.9968715,0.0005396879,0.001997616,0.00005791864,0.00002421704,0.000004329679,0.0001130778,0.000006558796,0.0003851605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00101719,"threshold_uncertainty_score":0.003402829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01715876573855162,"score_gpt":0.3464020624919832,"score_spread":0.3292432967534316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}