{"id":"W3197328793","doi":"10.1038/s41591-021-01488-2","title":"Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial","year":2021,"lang":"en","type":"article","venue":"Nature Medicine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":275,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; Juravinski Hospital; Royal University Hospital; Abbotsford Veterinary Clinic; Vitalité Health Network; Hôpital Maisonneuve-Rosemont; Vancouver General Hospital; Queensway-Carleton Hospital; Canadian Blood Services; Institut universitaire de cardiologie et de pneumologie de Québec; Grand River Hospital; Lakeridge Health; Centre Intégré de Santé et de Services Sociaux des Laurentides; St. Paul's Hospital; Centre Hospitalier Universitaire de Sherbrooke; Niagara Health System; Jewish General Hospital; Hôpital Charles-Le Moyne; Royal Jubilee Hospital; Mount Sinai Hospital; London Health Sciences Centre; North York General Hospital; McGill University Health Centre; Windsor Regional Hospital; Trillium Health Centre; Hamilton General Hospital; Victoria General Hospital; University Health Network; St Joseph's Health Centre; University of Toronto; University of Alberta; Rockyview General Hospital; University of Manitoba; Cegep de Saint Jerome; Ottawa Hospital; Impact; University of Waterloo; University of British Columbia; Sinai Health System; Regina General Hospital; St. Joseph’s Healthcare Hamilton; Health Sciences Centre; University of Calgary; Royal Alexandra Hospital; Markham Stouffville Hospital; Hôpital du Sacré-Cœur de Montréal; McMaster University; Centre intégré de santé et de services sociaux de Chaudière-Appalaches; Héma-Québec; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Public Health Agency of Canada; Kingston Health Sciences Centre; St. Boniface Hospital; Bausch Health (Canada); University of Ottawa; Sunnybrook Health Science Centre; The Scarborough Hospital; Public Health Ontario; Centre Hospitalier de l’Université de Montréal; Queen's University; Université Laval","funders":"Fonds de Recherche du Québec - Santé; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; University of Toronto; University of Alberta; Alberta Health Services; McMaster University; Ministry of Health, Saskatchewan; Health Sciences Centre Foundation; Government of Canada; Fondation du CHUM","keywords":"Medicine; Randomized controlled trial; Confidence interval; Odds ratio; Internal medicine; Relative risk; Convalescent plasma; Adverse effect; Intubation; Coronavirus disease 2019 (COVID-19); Anesthesia; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003940736,0.001579423,0.004185397,0.000446967,0.0005974282,0.001461928,0.001016885,0.003121263,0.007756674],"category_scores_gemma":[0.005844835,0.0005689486,0.00279508,0.0005892363,0.001216923,0.001525796,0.0004859262,0.003013386,0.0007707928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009263562,"about_ca_system_score_gemma":0.001481624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007616488,"about_ca_topic_score_gemma":0.001589653,"domain_scores_codex":[0.9975699,0.00161686,0.0002191862,0.0002645005,0.0001536596,0.0001759562],"domain_scores_gemma":[0.9975331,0.001072759,0.0006095322,0.0001469769,0.0001910127,0.000446573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9818614,0.003452467,0.0003439699,0.002308566,0.00158587,0.00004491598,0.00004022447,0.00009321002,0.0004357201,0.0001441868,0.0008762206,0.008813257],"study_design_scores_gemma":[0.9824414,0.01580402,0.0003775849,0.0001198641,0.000437471,0.00001342271,0.00001477183,0.0001466651,0.00005518021,0.0001109692,0.0004714225,0.000007409475],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9004465,0.05003415,0.00344413,0.004562797,0.004538134,0.02756132,0.003435068,0.000372697,0.005605237],"genre_scores_gemma":[0.9419569,0.01280584,0.004593542,0.004632649,0.001941905,0.02912884,0.001729461,0.00004048169,0.003170301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007756674,"threshold_uncertainty_score":0.0259487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03379855019210593,"score_gpt":0.3908244127627724,"score_spread":0.3570258625706664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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