{"id":"W3197362046","doi":"10.1093/braincomms/fcab201","title":"Amyloid-driven disruption of default mode network connectivity in cognitively healthy individuals","year":2021,"lang":"en","type":"article","venue":"Brain Communications","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alzheimer Nederland; ZonMw; University College London Hospitals NHS Foundation Trust; European Commission; University College London; National Institute for Health and Care Research; Alzheimer's Association; European Federation of Pharmaceutical Industries and Associations; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Weston Brain Institute","keywords":"Default mode network; Posterior cingulate; Precuneus; Neuroscience; Resting state fMRI; Psychology; Alzheimer's disease; Cortex (anatomy); Task-positive network; Medicine; Disease; Functional connectivity; Internal medicine; Functional magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002618224,0.0002441073,0.0001558069,0.0004572065,0.0002887383,0.0002662732,0.0001995664,0.0002657092,0.0008177411],"category_scores_gemma":[0.001277291,0.0001563159,0.0001542613,0.0002372746,0.0002834596,0.0002257921,0.0002154579,0.0002451095,0.00006466974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002663486,"about_ca_system_score_gemma":0.0001331419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005562405,"about_ca_topic_score_gemma":0.007939087,"domain_scores_codex":[0.9999129,0.00001851481,0.000007042638,0.00003882153,0.000009509488,0.00001317163],"domain_scores_gemma":[0.999747,0.00005634044,0.0000986876,0.00003081568,0.00002427439,0.00004290044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001473476,0.0002809479,0.9714646,0.00002937601,0.0001959433,0.0009367016,0.0009764397,0.0008569281,0.01401515,0.0003479055,0.0002785986,0.009144002],"study_design_scores_gemma":[0.00001211561,0.0001065974,0.9980801,0.000001559942,0.00001824996,0.0004095305,0.00006671931,0.0007411864,0.0002008002,0.0003179214,0.00004104523,0.000004068534],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997498,0.00001618923,0.00008913472,0.000008400318,5.495522e-7,0.000002986663,0.00004870848,0.000002776918,0.00008130271],"genre_scores_gemma":[0.9997968,0.000008586399,0.00008706371,0.000004378153,0.000001128943,0.000003269518,0.00004602475,7.736335e-7,0.00005191162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005562405,"threshold_uncertainty_score":0.01106006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08952474954878824,"score_gpt":0.3578007842141536,"score_spread":0.2682760346653654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}