{"id":"W3197403788","doi":"10.1093/braincomms/fcab189","title":"The link between brain acidosis, breathing and seizures: a novel mechanism of action for the ketogenic diet in a model of infantile spasms","year":2021,"lang":"en","type":"letter","venue":"Brain Communications","topic":"Diet and metabolism studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"Alberta Children's Hospital Research Institute; Branch Out Neurological Foundation; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Ketogenic diet; Ketosis; Medicine; Acidosis; Internal medicine; Epilepsy; Respiratory acidosis; Anesthesia; Encephalopathy; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000204382,0.000550609,0.0005193808,0.0004774313,0.000174384,0.0002860386,0.0003926982,0.0004195775,0.0008627792],"category_scores_gemma":[0.0001403729,0.0001380537,0.0002784151,0.0001607192,0.0005141214,0.0003554997,0.0003124752,0.000894058,0.0001276088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003221937,"about_ca_system_score_gemma":0.0003025808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003746974,"about_ca_topic_score_gemma":0.0006378295,"domain_scores_codex":[0.9998791,0.00002978698,0.00001181329,0.00001929573,0.00002522555,0.00003476253],"domain_scores_gemma":[0.9998491,0.00001533888,0.00004734144,0.0000220331,0.00001627939,0.00004982711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002254867,0.0004200506,0.0005608031,0.0001524496,0.00002088116,0.0005720756,0.00003436892,0.00008595111,0.9917871,0.0003657714,0.00009612508,0.00364947],"study_design_scores_gemma":[0.0003100365,0.01441881,0.01562775,0.00005963496,0.0001092532,0.001912764,0.0002456111,0.002085241,0.9605492,0.0005620453,0.004086774,0.00003276086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.9960045,0.001156935,0.00162824,0.0002582963,0.00004659572,0.00005386215,0.0001663234,0.00005014719,0.0006352119],"genre_scores_gemma":[0.994912,0.001384496,0.001877469,0.0001007657,0.00002044258,0.00009836677,0.0002215952,0.000007126739,0.001377977],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.0008627792,"threshold_uncertainty_score":0.002886295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1124282932610851,"score_gpt":0.3451750041675459,"score_spread":0.2327467109064608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}