{"id":"W3197412385","doi":"10.1158/1078-0432.ccr-21-1864","title":"Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous <i>KIT/PDGFRA</i> Mutations in the Phase III INVICTUS Study","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Cancer Institute; U.S. Food and Drug Administration; Deciphera Pharmaceuticals","keywords":"PDGFRA; Medicine; Exon; GiST; Internal medicine; Stromal tumor; Placebo; Tyrosine-kinase inhibitor; Mutation; Oncology; Gastroenterology; Cancer research; Pathology; Stromal cell; Biology; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008584347,0.0004451594,0.0009637732,0.0001521885,0.0001639014,0.0005463533,0.0002838238,0.0003483553,0.001027361],"category_scores_gemma":[0.0005563951,0.0001499407,0.000749805,0.0002136976,0.0002448297,0.0002842842,0.0001830275,0.001055021,0.0002540895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004631156,"about_ca_system_score_gemma":0.0005291142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003370735,"about_ca_topic_score_gemma":0.001254141,"domain_scores_codex":[0.9997346,0.0001310685,0.00001855,0.00004254049,0.0000373629,0.00003576438],"domain_scores_gemma":[0.9997073,0.00005494193,0.00009684671,0.00002277387,0.0000245281,0.00009354738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4975479,0.01474838,0.1042296,0.001609945,0.004743593,0.0005480921,0.0004235921,0.004964324,0.1053808,0.0003830119,0.009086751,0.2563339],"study_design_scores_gemma":[0.310829,0.282829,0.3654669,0.0001753023,0.003804421,0.002415796,0.0002651605,0.004762059,0.01700402,0.0006753842,0.01165798,0.0001150349],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947424,0.002656495,0.0001776638,0.0001407318,0.0000246496,0.0002214222,0.0004614157,0.00003168215,0.001543578],"genre_scores_gemma":[0.9971175,0.0007572124,0.000291936,0.0002344148,0.00003954542,0.0001350894,0.001022412,0.000007257909,0.0003946597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001027361,"threshold_uncertainty_score":0.004539907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1403114999829044,"score_gpt":0.5113444287207737,"score_spread":0.3710329287378692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}