{"id":"W3197475730","doi":"10.3390/ijms22189710","title":"The First Cytoplasmic Loop in the Core Structure of the ABCC1 (Multidrug Resistance Protein 1; MRP1) Transporter Contains Multiple Amino Acids Essential for Its Expression","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Queen's University","keywords":"Transmembrane domain; ATP-binding cassette transporter; ABCC1; Efflux; Cyclic nucleotide-binding domain; Amino acid; Biology; Mutant; Mutagenesis; Biochemistry; Multidrug Resistance-Associated Proteins; Transport protein; Transporter; Alanine; Transmembrane protein; Protein structure; Alanine scanning; Cytoplasm; Helix (gastropod); Peptide sequence; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009563463,0.000364523,0.0002985325,0.0001206116,0.0002535702,0.0002861376,0.0001954651,0.0003469659,0.001823381],"category_scores_gemma":[0.0001445836,0.0001208402,0.0003516489,0.0002252666,0.0002075151,0.0002027461,0.0002239102,0.0003931584,0.001052319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004428379,"about_ca_system_score_gemma":0.0003955938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009528112,"about_ca_topic_score_gemma":0.0007954706,"domain_scores_codex":[0.9999223,0.0000138496,0.000006450907,0.00002247915,0.00002176272,0.00001311936],"domain_scores_gemma":[0.9998825,0.00001504233,0.00003909651,0.00001118828,0.00002055851,0.00003166485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001593275,0.00001431889,0.0005310792,0.00005733246,0.000009040214,0.0003254303,0.00002065979,0.0002962726,0.9957784,0.0003582292,0.0001170836,0.002332869],"study_design_scores_gemma":[0.00008868563,0.0004428804,0.01756352,0.00003660792,0.0000599154,0.002305788,0.00008794387,0.003659696,0.9533619,0.0003814876,0.02198252,0.00002925055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853266,0.00120978,0.009898477,0.0002006132,0.00006101052,0.000042495,0.0008513484,0.000190209,0.002219385],"genre_scores_gemma":[0.9882683,0.000447591,0.006458986,0.0001143008,0.00001489895,0.00003245662,0.001729289,0.00003086324,0.002903329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001823381,"threshold_uncertainty_score":0.00609988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01234422900554574,"score_gpt":0.2692961785445227,"score_spread":0.256951949538977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}