{"id":"W3197489461","doi":"10.3390/cells10092322","title":"Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Université Laval","keywords":"Ethanolamine; Lipoxygenase; Chemistry; Endocannabinoid system; Biochemistry; Monoacylglycerol lipase; Ethanolamines; Glycerol; Lipid signaling; Hydrolysis; Linoleic acid; Arachidonate 5-lipoxygenase; Arachidonic acid; Stereochemistry; Enzyme; Fatty acid; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005405456,0.0005844719,0.001127469,0.0002589764,0.0004107185,0.0001344329,0.0003923467,0.000325149,0.0003007711],"category_scores_gemma":[0.0001653881,0.0004396781,0.000347609,0.0007708908,0.0008342125,0.0001615946,0.0005010245,0.0005951225,0.0000133773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009653468,"about_ca_system_score_gemma":0.0002874252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005610034,"about_ca_topic_score_gemma":0.0001072599,"domain_scores_codex":[0.9961315,0.0001879528,0.0007987943,0.001047824,0.0008274928,0.00100638],"domain_scores_gemma":[0.9972559,0.0001180574,0.0002883674,0.00127844,0.0004177192,0.0006415042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000111102,0.0006929472,0.001070034,0.0004596565,0.0002283832,0.0000986111,0.0006953483,0.000006945466,0.9910265,0.0003653632,0.003290431,0.001954724],"study_design_scores_gemma":[0.00294715,0.0004094598,0.01040558,0.0001740481,0.0004556947,0.0004518891,0.0002497814,0.0001446613,0.9461749,0.0001610938,0.037976,0.0004497352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691526,0.02310633,0.00001713819,0.003353988,0.000230609,0.000927642,0.0005473397,0.00005466439,0.002609728],"genre_scores_gemma":[0.9853352,0.001990929,0.0001085376,0.0007554459,0.0002849513,0.00006067719,0.00005489231,0.000114167,0.01129519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04485155,"threshold_uncertainty_score":0.9998055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01852345209525155,"score_gpt":0.2459716100662946,"score_spread":0.227448157971043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}