{"id":"W3197498721","doi":"10.1158/1078-0432.ccr-21-0261","title":"Safety and Antitumor Activity of α-PD-L1 Antibody as Monotherapy or in Combination with α-TIM-3 Antibody in Patients with Microsatellite Instability–High/Mismatch Repair–Deficient Tumors","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Eli Lilly and Company","keywords":"Antibody; Cancer; Combination therapy; Microsatellite; Immunotherapy; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006457093,0.0004994693,0.0008792505,0.0002294988,0.0002534126,0.0004533456,0.0001951826,0.0003502314,0.001481303],"category_scores_gemma":[0.0005027604,0.0001883016,0.0005445593,0.0001790493,0.0002368413,0.0003560548,0.0001366359,0.0009905702,0.0004200583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005689215,"about_ca_system_score_gemma":0.0005154447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002725488,"about_ca_topic_score_gemma":0.0008603607,"domain_scores_codex":[0.9997874,0.00009137845,0.00001892253,0.00003516338,0.00002299745,0.00004416169],"domain_scores_gemma":[0.9997379,0.00004649607,0.00006704462,0.00001704922,0.0000141449,0.0001172288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3352113,0.03039947,0.09463564,0.0008484411,0.001566712,0.001034585,0.0003808666,0.005124109,0.1784377,0.000275827,0.006112905,0.3459724],"study_design_scores_gemma":[0.1050177,0.7315112,0.116276,0.0001075642,0.00109195,0.002973522,0.0001450107,0.006143052,0.0282407,0.000215131,0.008235608,0.00004251091],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973013,0.001228839,0.0001910658,0.0001107497,0.00002335231,0.0001401257,0.0001237058,0.00002651061,0.0008544576],"genre_scores_gemma":[0.9983006,0.0003802212,0.0002914885,0.0001563031,0.000039259,0.0001267511,0.000222661,0.000005065423,0.0004776664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001481303,"threshold_uncertainty_score":0.004955411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05442876539091771,"score_gpt":0.4418841858398773,"score_spread":0.3874554204489595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}