{"id":"W3197511105","doi":"10.3389/fphar.2021.713486","title":"Activation of Antioxidant and Proteolytic Pathways in the Nigrostriatal Dopaminergic System After 3,4-Methylenedioxymethamphetamine Administration: Sex-Related Differences","year":2021,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université du Québec à Trois-Rivières; Université du Québec à Montréal","funders":"Università di Bologna; Fondazione di Sardegna","keywords":"MDMA; SOD2; Dopaminergic; Internal medicine; Striatum; Endocrinology; Dopamine; Ecstasy; Midbrain; Tyrosine hydroxylase; Glutathione peroxidase; Amphetamine; Dopaminergic pathways; Substantia nigra; Superoxide dismutase; Pharmacology; Chemistry; Medicine; Central nervous system; Oxidative stress; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008365719,0.0002367359,0.0001924111,0.000343549,0.0001280971,0.0001626554,0.0001199882,0.0002639732,0.001616396],"category_scores_gemma":[0.00007748584,0.0001301857,0.0002348307,0.0001296732,0.0001587635,0.0002122627,0.0001272379,0.0003017733,0.0002056826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001326652,"about_ca_system_score_gemma":0.0001117673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003156953,"about_ca_topic_score_gemma":0.0005226356,"domain_scores_codex":[0.9999337,0.000007678576,0.000005372722,0.00002161312,0.00001352148,0.00001810191],"domain_scores_gemma":[0.999909,0.000004954335,0.00003415011,0.000006651076,0.00001751677,0.00002778355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008048809,0.00009387317,0.004797918,0.00006026785,0.00002165891,0.0002458015,0.00006034895,0.00001574365,0.9895355,0.00006110553,0.0000437663,0.004259134],"study_design_scores_gemma":[0.00005333353,0.002239125,0.4083865,0.00002280965,0.0000974874,0.001705531,0.0002155644,0.0003819477,0.5846041,0.0002042786,0.002072948,0.00001632344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959687,0.002674524,0.0003741283,0.00005812048,0.00001719989,0.00001129889,0.0002922405,0.00001780228,0.0005858806],"genre_scores_gemma":[0.9947594,0.001424407,0.0003963492,0.00005935391,0.00001559659,0.00004340347,0.0004119552,0.00000756626,0.002881954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001616396,"threshold_uncertainty_score":0.005407333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02159628185295934,"score_gpt":0.2657398596642024,"score_spread":0.2441435778112431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}