{"id":"W3197532225","doi":"10.1002/hep4.1787","title":"Adjunct Fenofibrate Up‐regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis","year":2021,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences","keywords":"Fenofibrate; Glucuronidation; Internal medicine; Ursodeoxycholic acid; Cholestasis; Endocrinology; Deoxycholic acid; Bile acid; Chenodeoxycholic acid; Chemistry; Lithocholic acid; Cholestasis of pregnancy; Primary sclerosing cholangitis; Medicine; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009248291,0.0001400254,0.000264644,0.00007218726,0.0002828733,0.00001592967,0.00008660128,0.00008853433,0.00002004621],"category_scores_gemma":[0.00004431838,0.000105613,0.00005773648,0.0001507302,0.0001845801,0.00007308515,0.00003911736,0.00006835909,0.000004478892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006562603,"about_ca_system_score_gemma":0.0002264445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001353837,"about_ca_topic_score_gemma":0.0002610378,"domain_scores_codex":[0.9992049,0.0001139661,0.0002019726,0.0002304406,0.00007113408,0.000177546],"domain_scores_gemma":[0.9984515,0.0001860488,0.00008129533,0.0009729324,0.000224452,0.00008380374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01600852,0.005765957,0.5799115,0.0004052697,0.001556062,0.0000604664,0.004307818,0.000002118198,0.2961617,0.01331305,0.0006329863,0.08187464],"study_design_scores_gemma":[0.01714795,0.003464728,0.5777068,0.0002311155,0.001356959,0.0001105372,0.001045869,0.0008119256,0.3033992,0.001177125,0.09295513,0.0005926659],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914718,0.001323771,0.0005837732,0.005661625,0.0000680821,0.0006175725,0.00008722657,0.0000523731,0.0001337478],"genre_scores_gemma":[0.9807678,0.0008235539,0.01565499,0.0001505703,0.000007966858,0.0002455402,0.001183619,0.00002345068,0.001142499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09232214,"threshold_uncertainty_score":0.4306771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0194991679242249,"score_gpt":0.2706066701823187,"score_spread":0.2511075022580938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}