{"id":"W3197561900","doi":"10.3390/molecules26185460","title":"Molecular Determinant of DIDS Analogs Targeting RAD51 Activity","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Conseil Régional des Pays de la Loire","keywords":"RAD51; DIDS; Homologous recombination; Chemistry; Biochemistry; Cell biology; Biology; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001352224,0.0001663929,0.0002025133,0.00003433039,0.00004342112,0.00001505454,0.0001781375,0.0001401438,0.00001920386],"category_scores_gemma":[0.0002001754,0.0001726,0.0001795387,0.0001228974,0.00006279075,0.000003348885,0.0002398171,0.00007791343,0.000004804787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001072954,"about_ca_system_score_gemma":0.00009803352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001312204,"about_ca_topic_score_gemma":0.000009915711,"domain_scores_codex":[0.9988439,0.0001208886,0.0001940824,0.0004051526,0.0001763952,0.0002595659],"domain_scores_gemma":[0.9992181,0.00000983401,0.0001036852,0.000466737,0.0001264779,0.00007514084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002451289,0.00007906408,0.0003683539,0.00003161338,0.00005100568,0.0001253096,0.00001755533,0.00006468261,0.9947693,0.0002847739,0.0001404673,0.004043374],"study_design_scores_gemma":[0.0002590235,0.000132012,0.0007164668,0.00001648217,0.00002501082,0.00003045841,0.00003628686,0.0002593897,0.9960788,0.0001969615,0.00205961,0.000189447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802586,0.0009666416,0.01731804,0.00006708336,0.0001080313,0.00008223359,0.00001628982,0.00001753788,0.001165486],"genre_scores_gemma":[0.9931886,0.00006143346,0.006272478,0.0001358552,0.000043551,0.00001194766,0.00006380505,0.0000319837,0.0001903946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01292989,"threshold_uncertainty_score":0.7038425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006209331868659424,"score_gpt":0.2359390505077886,"score_spread":0.2297297186391291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}