{"id":"W3197561900","doi":"10.3390/molecules26185460","title":"Molecular Determinant of DIDS Analogs Targeting RAD51 Activity","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Conseil Régional des Pays de la Loire","keywords":"RAD51; DIDS; Homologous recombination; Chemistry; Biochemistry; Cell biology; Biology; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168735,0.0002730505,0.0001872528,0.0001296048,0.00009539654,0.0001715295,0.0002304441,0.0002715743,0.001336454],"category_scores_gemma":[0.0001748105,0.00009622741,0.0001668317,0.0001200781,0.0001881663,0.0001422098,0.0001115932,0.0004991978,0.0002548343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000277572,"about_ca_system_score_gemma":0.0001104244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001953999,"about_ca_topic_score_gemma":0.0002799517,"domain_scores_codex":[0.9999076,0.00001904873,0.000009493836,0.00002330705,0.00002050471,0.00001999094],"domain_scores_gemma":[0.9998507,0.00004139819,0.00004282338,0.00001751013,0.00001762446,0.0000298924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006249912,0.00004217102,0.00007413988,0.00002931843,0.000003460367,0.00002764116,0.000006730088,0.0001518687,0.9986295,0.0001519749,0.0000229185,0.0007978062],"study_design_scores_gemma":[0.00001566799,0.0003589995,0.0003903977,0.000002207259,0.000006968701,0.00005719107,0.000005952942,0.0003367097,0.9973989,0.00001810868,0.001406241,0.000002575443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912627,0.001807901,0.003771378,0.0001324613,0.00004140958,0.00006661504,0.0002009338,0.00005047513,0.002666215],"genre_scores_gemma":[0.9939088,0.000788089,0.00326729,0.00005646123,0.0000137515,0.00003687861,0.0003254379,0.00001307076,0.00159016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001336454,"threshold_uncertainty_score":0.004470885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006209331868659424,"score_gpt":0.2359390505077886,"score_spread":0.2297297186391291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}