{"id":"W3197572801","doi":"10.1164/rccm.202009-3539oc","title":"Effect of Esophageal Pressure–guided Positive End-Expiratory Pressure on Survival from Acute Respiratory Distress Syndrome: A Risk-based and Mechanistic Reanalysis of the EPVent-2 Trial","year":2021,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Respiratory Support and Mechanisms","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University; St. Joseph's Hospital","funders":"National Heart, Lung, and Blood Institute","keywords":"Transpulmonary pressure; Mechanical ventilation; Confidence interval; Positive end-expiratory pressure; ARDS; Respiratory physiology; Fraction of inspired oxygen; Acute respiratory distress; Central venous pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001772779,0.0004701107,0.002213378,0.0002808892,0.0001841893,0.00002024709,0.000276424,0.0001937422,0.0001724256],"category_scores_gemma":[0.003394696,0.0002983374,0.000485364,0.0005593019,0.001895953,0.0001022009,0.0001077436,0.0008753974,5.229263e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004675949,"about_ca_system_score_gemma":0.000592089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006298397,"about_ca_topic_score_gemma":0.00001012565,"domain_scores_codex":[0.9936208,0.002546345,0.001405537,0.000556051,0.00149633,0.0003750081],"domain_scores_gemma":[0.9939954,0.002391612,0.001123898,0.0007447921,0.001133673,0.0006106074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2394854,0.002870678,0.2611281,0.007067952,0.01655898,0.02112572,0.004833547,0.0001098544,0.267635,0.004914606,0.001314076,0.172956],"study_design_scores_gemma":[0.1054296,0.1905027,0.06797417,0.00598883,0.05500467,0.0006321591,0.007712583,0.00009154919,0.5579628,0.0003516118,0.007216428,0.001132961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854729,0.01203702,0.0003699483,0.0003286305,0.0005869908,0.0004890007,0.0005441355,0.0000135711,0.0001578167],"genre_scores_gemma":[0.998248,0.00005033502,0.0001081342,0.001081524,0.0004141611,0.0000157834,0.00001659033,0.00004480403,0.00002066827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2903278,"threshold_uncertainty_score":0.9999469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01238077840067395,"score_gpt":0.310987425969816,"score_spread":0.298606647569142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}