{"id":"W3197618404","doi":"10.1007/s12028-021-01326-w","title":"Neuronal Swelling: A Non-osmotic Consequence of Spreading Depolarization","year":2021,"lang":"en","type":"article","venue":"Neurocritical Care","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Depolarization; Swelling; Ischemia; Biophysics; Aquaporin; Cerebral edema; Edema; Tonicity; Neuron; Osmosis; Osmotic concentration; Aquaporin 4; Neuroscience; Medicine; Anesthesia; Chemistry; Internal medicine; Biochemistry; Biology; Membrane; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00001797843,0.00007986511,0.00008960963,0.00001771176,0.00004102105,0.00001046926,0.00005957725,0.00007902507,0.00001816336],"category_scores_gemma":[0.00007210868,0.00008891124,0.00006744011,0.00008015915,0.00006278524,0.000003417752,0.00002072686,0.00006738946,0.000002276255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004372477,"about_ca_system_score_gemma":0.00007926922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002689576,"about_ca_topic_score_gemma":0.000005854392,"domain_scores_codex":[0.9993321,0.00002733609,0.0001524002,0.000226039,0.0001252647,0.0001369163],"domain_scores_gemma":[0.9995156,0.00001242472,0.00002032064,0.0001444152,0.0002492446,0.00005798816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002097391,0.00002303567,0.003194627,0.0001016607,0.00000455039,0.00007215208,0.00003707839,0.0001697057,0.9955953,0.000402143,0.00001581817,0.0003629519],"study_design_scores_gemma":[0.0002088748,0.0001089528,0.01188673,0.00002350617,0.00002254762,0.00007311453,0.0001222204,0.0002347361,0.9865741,0.00009718913,0.0005551333,0.00009295236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846793,0.0002673507,0.01392296,0.0001339532,0.0001664252,0.00005378632,0.00001613667,0.00000791558,0.0007522171],"genre_scores_gemma":[0.998961,0.00002981798,0.0002998054,0.0002483227,0.000109555,0.000002731331,0.0002777584,0.00001355236,0.00005751364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01428169,"threshold_uncertainty_score":0.3625695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007464735067561433,"score_gpt":0.2363331026637147,"score_spread":0.2288683675961532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}