{"id":"W3197618404","doi":"10.1007/s12028-021-01326-w","title":"Neuronal Swelling: A Non-osmotic Consequence of Spreading Depolarization","year":2021,"lang":"en","type":"article","venue":"Neurocritical Care","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Depolarization; Swelling; Ischemia; Biophysics; Aquaporin; Cerebral edema; Edema; Tonicity; Neuron; Osmosis; Osmotic concentration; Aquaporin 4; Neuroscience; Medicine; Anesthesia; Chemistry; Internal medicine; Biochemistry; Biology; Membrane; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001494108,0.0003347027,0.0003011789,0.0003829636,0.0001456519,0.0005090689,0.0002573701,0.000617408,0.001256827],"category_scores_gemma":[0.0002717216,0.00008273161,0.0003034909,0.0002359585,0.0004678141,0.0005715532,0.0003996982,0.0007303071,0.0004778953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002775569,"about_ca_system_score_gemma":0.00012367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002272987,"about_ca_topic_score_gemma":0.0002246971,"domain_scores_codex":[0.9998679,0.00002352878,0.00001970823,0.00001817107,0.00004321971,0.00002745714],"domain_scores_gemma":[0.9998164,0.00003621619,0.00006424167,0.00001280126,0.00004953803,0.00002080098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005270747,0.00007539733,0.003631163,0.004285578,0.0001360397,0.02133015,0.0003492745,0.0006630272,0.8487214,0.01237545,0.01012972,0.09777561],"study_design_scores_gemma":[0.0001069737,0.001532526,0.04701176,0.0009951605,0.0004360163,0.1237359,0.0008607256,0.003356487,0.6109368,0.03839525,0.1724354,0.0001969628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3820934,0.546427,0.02603519,0.007876964,0.003053819,0.0001574521,0.0008376964,0.0006498353,0.03286857],"genre_scores_gemma":[0.8688559,0.1194782,0.002210946,0.001903108,0.00125778,0.00006341287,0.0003562138,0.0000386427,0.00583587],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001256827,"threshold_uncertainty_score":0.004204512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007464735067561433,"score_gpt":0.2363331026637147,"score_spread":0.2288683675961532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}