{"id":"W3197649229","doi":"10.1002/ehf2.13517","title":"The Genomics of Heart Failure: Design and Rationale of the HERMES Consortium","year":2021,"lang":"en","type":"article","venue":"ESC Heart Failure","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Amgen (Canada); Université de Montréal; Montreal Heart Institute","funders":"National Heart, Lung, and Blood Institute; UCLH Biomedical Research Centre; American Regent; National Institutes of Health; Roy J. and Lucille A. Carver College of Medicine, University of Iowa; Esperion Therapeutics; European Research Council; Terveyden ja hyvinvoinnin laitos; Karl-Franzens-Universität Graz; University College London Hospitals NHS Foundation Trust; Medical Research Council; Servier; Uppsala Universitet; Aalborg Universitetshospital; Medizinische Universität Wien; Medical Center, University of Pittsburgh; Turun Yliopisto; Skånes universitetssjukhus; Rigshospitalet; Netherlands Heart Institute; Universitair Medisch Centrum Groningen; Leids Universitair Medisch Centrum; Vetenskapsrådet; Eisai; Lunds Universitet; Crafoordska Stiftelsen; Regeneron Pharmaceuticals; Universität Wien; University of Glasgow; Universiteit Leiden; Stiftelsen för Strategisk Forskning; McMaster University; University of Oxford; Hjärt-Lungfonden; Framingham Heart Study; American Heart Association; Evans Medical Foundation; Health Data Research UK; Brigham and Women's Hospital; European Federation of Pharmaceutical Industries and Associations; Department of Orthopaedic Surgery, Boston University School of Medicine; Amgen; Université de Montréal; Ohio State University; Háskóli Íslands; British Heart Foundation; Stiftelsen för Strategisk Forskning; University of Pittsburgh; NIHR Leicester Biomedical Research Centre; Medizinische Universität Graz; U.S. Department of Veterans Affairs; Yale University; Office of Research and Development; UK Research and Innovation; Massachusetts General Hospital; Aalborg Universitet; Eli Lilly and Company; National Center for Advancing Translational Sciences; Kaiser Permanente; GlaxoSmithKline; National Institute of Diabetes and Digestive and Kidney Diseases; Turun Yliopistollinen Keskussairaala; Knut och Alice Wallenbergs Stiftelse; Bayer; Gentofte Hospital; National Institute for Health and Care Research; CSL Behring; Rijksuniversiteit Groningen; University of Leicester; Bristol-Myers Squibb; Amarin Corporation; Erasmus Universitair Medisch Centrum Rotterdam; Genentech; AstraZeneca; University of Washington; Pfizer; Sanofi; Broad Institute; School of Medicine, Boston University","keywords":"Heart failure; Medicine; Genomics; Internal medicine; Intensive care medicine; Genetics; Biology; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003704678,0.00009248438,0.0002669833,0.00002232346,0.0001470094,0.00001607205,0.00004463777,0.00007978667,0.0001204057],"category_scores_gemma":[0.0002153355,0.00005287325,0.0002604813,0.0001736154,0.0001800874,0.00003018056,0.00004608836,0.0001667896,0.000007919525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002081333,"about_ca_system_score_gemma":0.0003555301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001810489,"about_ca_topic_score_gemma":0.00005414347,"domain_scores_codex":[0.9990265,0.0001916731,0.000234928,0.0001526552,0.0002684366,0.0001257876],"domain_scores_gemma":[0.9990665,0.0002120229,0.00005419943,0.0004030705,0.0001998812,0.00006432115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002356567,0.0001906315,0.2201755,0.0002374567,0.0009775913,0.00001041757,0.001124389,0.0004753023,0.3473278,0.0024496,0.4251902,0.001605479],"study_design_scores_gemma":[0.0007517464,0.00004862456,0.09816826,0.00004658736,0.0001145986,0.000242263,0.001051044,0.0000742225,0.1020275,0.00008834481,0.7973152,0.00007162641],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9304535,0.002998255,0.0008324498,0.06431177,0.0004483901,0.0007884804,0.00001583135,0.00002721097,0.0001241216],"genre_scores_gemma":[0.9922608,0.0001624388,0.005526299,0.0006039524,0.000124517,0.00001074446,0.000007638491,0.00001724398,0.001286369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.372125,"threshold_uncertainty_score":0.2156109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01337902001194537,"score_gpt":0.2279852270869561,"score_spread":0.2146062070750107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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