{"id":"W3197649229","doi":"10.1002/ehf2.13517","title":"The Genomics of Heart Failure: Design and Rationale of the HERMES Consortium","year":2021,"lang":"en","type":"article","venue":"ESC Heart Failure","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Amgen (Canada); Université de Montréal; Montreal Heart Institute","funders":"National Heart, Lung, and Blood Institute; UCLH Biomedical Research Centre; American Regent; National Institutes of Health; Roy J. and Lucille A. Carver College of Medicine, University of Iowa; Esperion Therapeutics; European Research Council; Terveyden ja hyvinvoinnin laitos; Karl-Franzens-Universität Graz; University College London Hospitals NHS Foundation Trust; Medical Research Council; Servier; Uppsala Universitet; Aalborg Universitetshospital; Medizinische Universität Wien; Medical Center, University of Pittsburgh; Turun Yliopisto; Skånes universitetssjukhus; Rigshospitalet; Netherlands Heart Institute; Universitair Medisch Centrum Groningen; Leids Universitair Medisch Centrum; Vetenskapsrådet; Eisai; Lunds Universitet; Crafoordska Stiftelsen; Regeneron Pharmaceuticals; Universität Wien; University of Glasgow; Universiteit Leiden; Stiftelsen för Strategisk Forskning; McMaster University; University of Oxford; Hjärt-Lungfonden; Framingham Heart Study; American Heart Association; Evans Medical Foundation; Health Data Research UK; Brigham and Women's Hospital; European Federation of Pharmaceutical Industries and Associations; Department of Orthopaedic Surgery, Boston University School of Medicine; Amgen; Université de Montréal; Ohio State University; Háskóli Íslands; British Heart Foundation; Stiftelsen för Strategisk Forskning; University of Pittsburgh; NIHR Leicester Biomedical Research Centre; Medizinische Universität Graz; U.S. Department of Veterans Affairs; Yale University; Office of Research and Development; UK Research and Innovation; Massachusetts General Hospital; Aalborg Universitet; Eli Lilly and Company; National Center for Advancing Translational Sciences; Kaiser Permanente; GlaxoSmithKline; National Institute of Diabetes and Digestive and Kidney Diseases; Turun Yliopistollinen Keskussairaala; Knut och Alice Wallenbergs Stiftelse; Bayer; Gentofte Hospital; National Institute for Health and Care Research; CSL Behring; Rijksuniversiteit Groningen; University of Leicester; Bristol-Myers Squibb; Amarin Corporation; Erasmus Universitair Medisch Centrum Rotterdam; Genentech; AstraZeneca; University of Washington; Pfizer; Sanofi; Broad Institute; School of Medicine, Boston University","keywords":"Heart failure; Medicine; Genomics; Internal medicine; Intensive care medicine; Genetics; Biology; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1755542,0.001831356,0.001361778,0.003141619,0.004338149,0.004278204,0.003842445,0.003091649,0.01140182],"category_scores_gemma":[0.073035,0.001254289,0.001723364,0.003491503,0.005143409,0.002331386,0.01223277,0.002705476,0.001961058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002657707,"about_ca_system_score_gemma":0.01524436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005564152,"about_ca_topic_score_gemma":0.005555744,"domain_scores_codex":[0.8411779,0.1381053,0.00355587,0.006758009,0.007302754,0.003100218],"domain_scores_gemma":[0.9436908,0.01945534,0.004523977,0.01255694,0.01073786,0.009035229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.06146301,0.00465162,0.2099784,0.003739408,0.003786076,0.002305494,0.00897721,0.01428328,0.005079641,0.386497,0.05283633,0.2464025],"study_design_scores_gemma":[0.08504369,0.02085056,0.1778605,0.008556109,0.005628335,0.002602377,0.008943475,0.02388687,0.00996004,0.2008381,0.4548972,0.000932777],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.2142914,0.009682196,0.2576863,0.04090868,0.00330081,0.3716018,0.02239319,0.0006317979,0.07950376],"genre_scores_gemma":[0.2843063,0.00146291,0.2194904,0.008247297,0.001634807,0.4709694,0.006085669,0.000147478,0.007655714],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1755542,"threshold_uncertainty_score":0.9284304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01337902001194537,"score_gpt":0.2279852270869561,"score_spread":0.2146062070750107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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