{"id":"W3197658126","doi":"10.7554/elife.68918.sa2","title":"Author response: Linker histone H1.8 inhibits chromatin binding of condensins and DNA topoisomerase II to tune chromosome length and individualization","year":2021,"lang":"en","type":"peer-review","venue":"","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Chromatin; Topoisomerase; Linker; Linker DNA; Chromosome; Histone; DNA; Histone H1; Cell biology; Chemistry; Genetics; Molecular biology; Biology; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001231498,0.0004130471,0.0004156838,0.0005292292,0.0006634646,0.001483604,0.0006986603,0.001849902,0.1985151],"category_scores_gemma":[0.004949097,0.0002884648,0.0002623298,0.0002129611,0.0006046449,0.0004878078,0.0009457163,0.001672952,0.06199547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000836901,"about_ca_system_score_gemma":0.001411924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001068021,"about_ca_topic_score_gemma":0.002520413,"domain_scores_codex":[0.9989624,0.0001387938,0.00004598253,0.0001545937,0.0005735149,0.0001246808],"domain_scores_gemma":[0.9956465,0.0007638651,0.0002904646,0.0002360272,0.002353804,0.0007093655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001561217,0.0001399357,0.001709687,0.0007068627,0.00007930047,0.000647034,0.0002173638,0.0005934297,0.1102441,0.004447076,0.8026839,0.07697015],"study_design_scores_gemma":[0.0001660034,0.0002038784,0.003348316,0.00005586168,0.0000236297,0.0004062399,0.0003370354,0.0005810849,0.06930255,0.001447045,0.924098,0.00003041402],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.100316,0.01704631,0.01298063,0.3227276,0.1954443,0.001034917,0.007012235,0.005867379,0.3375707],"genre_scores_gemma":[0.06759699,0.002104398,0.001611092,0.0100676,0.004503686,0.00006324855,0.001338387,0.0004627153,0.9122518],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.1985151,"threshold_uncertainty_score":0.6640993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03288988028831652,"score_gpt":0.3403575272925918,"score_spread":0.3074676470042753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}