{"id":"W3197671904","doi":"10.1093/toxres/tfab085","title":"Effect of titanium dioxide nanoparticles on DNA methylation of human peripheral blood mononuclear cells","year":2021,"lang":"en","type":"article","venue":"Toxicology Research","topic":"Hydrogen's biological and therapeutic effects","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Kerman University of Medical Sciences; Iran National Science Foundation; National Science Foundation","keywords":"Peripheral blood mononuclear cell; Peripheral blood; Titanium dioxide; DNA methylation; DNA; Methylation; Silicon dioxide; Nanoparticle; Peripheral; Medicine; Materials science; Chemistry; Immunology; Biochemistry; In vitro; Nanotechnology; Internal medicine; Metallurgy; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003294645,0.0002785999,0.0002658516,0.0001668253,0.0001247003,0.0002018623,0.0001559172,0.0003459256,0.0008308708],"category_scores_gemma":[0.0004184553,0.0001243874,0.0002623426,0.0001334685,0.0001238165,0.0001066475,0.0001205812,0.0002613291,0.0001838112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001421019,"about_ca_system_score_gemma":0.0001598682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008237773,"about_ca_topic_score_gemma":0.001245738,"domain_scores_codex":[0.9996357,0.0001313585,0.00002998383,0.00007115338,0.00009078448,0.00004096811],"domain_scores_gemma":[0.9998208,0.00007734323,0.00002989963,0.00001427875,0.00004388456,0.00001388356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002190542,0.00003481248,0.0003987048,0.000102038,0.00001850334,0.00003678986,0.0000268416,0.00009441442,0.9964936,0.00001186565,0.00003692772,0.00252644],"study_design_scores_gemma":[0.00001256875,0.001166545,0.003963651,0.00001210045,0.0000327837,0.0001152109,0.00003923915,0.0004557705,0.99313,0.00002189691,0.001045183,0.000004983719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851062,0.008753121,0.00383741,0.0001236223,0.00007146732,0.00006001445,0.0003129693,0.00004433632,0.00169082],"genre_scores_gemma":[0.9918776,0.001863638,0.003746933,0.0001523822,0.0000197606,0.00008099753,0.0003471987,0.00001014882,0.001901453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008308708,"threshold_uncertainty_score":0.002779484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05597558598788731,"score_gpt":0.398776241429908,"score_spread":0.3428006554420207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}