{"id":"W3197768656","doi":"10.3233/jad-210462","title":"Assessing Genetic Overlap and Causality Between Blood Plasma Proteins and Alzheimer’s Disease","year":2021,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; National Institute on Aging; National Institute for Health Research Applied Research Collaboration South London; Menzies Centre for Australian Studies, King's College London, University of London; University of California, San Diego; Alzheimer's Society; Canadian Institutes of Health Research; Pfizer; University of California, Los Angeles; Engineering and Physical Sciences Research Council; AstraZeneca; European Commission; Genentech; National Institutes of Health; H. Lundbeck A/S; Medical Research Council; Servier; Innovative Medicines Initiative; University College London Hospitals NHS Foundation Trust; Foundation for the National Institutes of Health; King's College Hospital NHS Foundation Trust; Eisai; Public Health Agency; South London and Maudsley NHS Foundation Trust; Bayer HealthCare; King's College London; University of Cambridge; Medpace; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Bundesministerium für Bildung und Forschung; British Heart Foundation; National Institute for Health and Care Research; Economic and Social Research Council; Novartis Pharmaceuticals Corporation; UK Research and Innovation; Maudsley Charity; Northern California Institute for Research and Education; Synarc; Biogen; Health and Social Care Research and Development Division; BioClinica; Alfried Krupp von Bohlen und Halbach-Stiftung; European Federation of Pharmaceutical Industries and Associations; Alzheimer's Association; Amorfix Life Sciences; F. Hoffmann-La Roche; Scottish Government; Cardiff University; Eli Lilly and Company; Bristol-Myers Squibb; University College London; Wellcome Trust; Alzheimer's Disease Neuroimaging Initiative; Department of Health and Social Care; Meso Scale Diagnostics","keywords":"Disease; Causality (physics); Blood proteins; Alzheimer's disease; Computational biology; Neuroscience; Medicine; Biology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01584721,0.0005705786,0.0007681414,0.003971966,0.0002966161,0.0009050281,0.0004920581,0.0005968201,0.001388839],"category_scores_gemma":[0.02809378,0.0002497458,0.001674035,0.003360465,0.0006243691,0.0005945031,0.000728565,0.0004520867,0.000142044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002443222,"about_ca_system_score_gemma":0.0007207693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001072975,"about_ca_topic_score_gemma":0.00144254,"domain_scores_codex":[0.9901165,0.0068062,0.0008174328,0.001200783,0.0008864294,0.0001726189],"domain_scores_gemma":[0.9482486,0.04052385,0.008151665,0.001410461,0.001270519,0.0003948521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001737469,0.00006127277,0.9502504,0.0009130135,0.00528164,0.0002588377,0.0001275026,0.0006420891,0.001717283,0.0004160794,0.0001968821,0.03839745],"study_design_scores_gemma":[0.000254373,0.001568281,0.975246,0.0003455007,0.009371936,0.001765054,0.0003546632,0.004370686,0.001594408,0.003544501,0.00154044,0.000044087],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744197,0.01619296,0.006999738,0.0004423023,0.00003040279,0.00007957024,0.0005677642,0.00004039571,0.001227117],"genre_scores_gemma":[0.993771,0.001681149,0.004051979,0.0000702099,0.0000337356,0.00002938758,0.0002837095,0.000003716601,0.00007515008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01584721,"threshold_uncertainty_score":0.08380914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03685930302697222,"score_gpt":0.3120504426969377,"score_spread":0.2751911396699655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}