{"id":"W3197792981","doi":"10.1038/s41598-021-97140-7","title":"HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; McGill University Health Centre; Dalhousie University; Montreal Neurological Institute and Hospital","funders":"National Cancer Institute; National Health and Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Ministry of Education, India; Virginia Commonwealth University; Vetenskapsrådet; National Institute of Mental Health; Stockholms Läns Landsting; Fondation pour la Recherche Médicale; Ministerstvo Školství, Mládeže a Tělovýchovy; Bundesministerium für Bildung und Forschung; Grantová Agentura České Republiky; Centro de Investigación Biomédica en Red de Salud Mental; Karolinska Institutet; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; University of Oxford; U.S. Department of Veterans Affairs; University of New South Wales; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Fondation FondaMental; Deutsche Forschungsgemeinschaft; University of Louisville; Broad Institute; Johns Hopkins University; National Institute on Drug Abuse; Stanley Center for Psychiatric Research, Broad Institute; University of Pennsylvania; Rush University; Wayne State University; National Science Foundation","keywords":"Human leukocyte antigen; Bipolar disorder; Immunology; Allele; Medicine; Genetics; Lithium (medication); Biology; Psychiatry; Antigen; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003615659,0.0001869896,0.0002331054,0.0002835823,0.000249461,0.0004823322,0.000147841,0.0002904384,0.003954014],"category_scores_gemma":[0.001127127,0.0001034547,0.0002562301,0.0004630048,0.0001713572,0.0001672537,0.0001634415,0.0003826642,0.0002634286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000154503,"about_ca_system_score_gemma":0.00009011869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002083134,"about_ca_topic_score_gemma":0.001774529,"domain_scores_codex":[0.9997392,0.0001210993,0.00002080207,0.00005320101,0.00002297074,0.00004259467],"domain_scores_gemma":[0.999426,0.0001347838,0.0002512803,0.00003314545,0.00004507705,0.0001097775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001625839,0.0000799051,0.9861134,0.00003297884,0.0002442048,0.0001725771,0.0001265538,0.00007747623,0.004898639,0.00006185232,0.0003663195,0.006200274],"study_design_scores_gemma":[0.00002483019,0.00009477798,0.9989542,0.00000928566,0.00006030847,0.0001971005,0.00008860417,0.0001444901,0.0001264402,0.0000895647,0.0002079354,0.00000243121],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983955,0.0006221526,0.0001055076,0.0001445706,0.00001368804,0.000004145454,0.0001715354,0.000003279455,0.0005396347],"genre_scores_gemma":[0.999564,0.00007687822,0.00005390638,0.00005315523,0.00001041664,0.000002631484,0.00008492513,0.000002063184,0.0001520322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003954014,"threshold_uncertainty_score":0.01322752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008748288840626844,"score_gpt":0.2417794795100762,"score_spread":0.2330311906694494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}